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EC number: 247-148-4
CAS number: 25637-99-4
HBCDD did not induce sensitisation in a mouse local lymph node assay or
in a guinea pig maximisation study. Both studies were conducted
according to international guidelines and GLP using a composite of
commercial products from three manufacturers (i.e. Albemarle, Chemtura
and ICL-IP). Earlier studies performed in Japan using a test substance
of unknown composition reported positive results. These studies were not
conducted according to GLP nor current guidelines. For the test
substance provided by Albemarle, Chemtura and ICL-IP it can be concluded
that HBCDD does not have skin sensitising potential. This was also
concluded in the EU Risk Assessment Report (EC, 2008).
No information was available for respiratory sensitisation. As HBCDD is
not a skin sensitiser and no cases of respiratory sensitisation have
been reported in the literature, the substance is unlikely to have
respiratory sensitisation potential.
Based upon the results of the key study (Woolhiser and Anderson, 2003),
HBCDD does not meet the criteria for classification according to
67/548/EEC and EC Regulation 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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