Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

The following information is available for the following investigations.
- Basic Toxicokinetics, metabolism and distribution investigations:
Germer, S., Piersma, A. H., van der Ven, L., Kamyschnikow, A., Fery, Y., Schmitz, H. -J. & Schrenk, D. (2006). Subacute effects of the brominated flame retardants hexabromocyclododecane and tetrabromobisphenol A on hepatic cytochrome P450 levels in rats. Toxicology (2006) Vol. 218, pp. 229-236.
Scholz, A., Abrahamsson, B., Diebold, S. M., Kostewicz, E., Polentarutti, B. I., Ungell, A. -L., Dressman, J. B. (2002). Influence of Hydrodynamics and Particle Size on the Absorption of Felodipine in Labradors. Pharmaceutical Research (2002), Vol. 19(1).
Canton, R. F., Peijnenburg, A. A. C. M, Hoogenboom, R. L. A. P, Piersma, A. H., van der Ven, L. T. M., van der Berg, M. & Heneweer, M. (2008). Subacute effects of hexabromocyclododecane (HBCD) on hepatic gene expression profiles in rats. Toxicology and Applied Pharmacology (2008), Vol 231, pp. 267-272.
Zeger, B. N., Mets, A., van Bommel, R., Minkenberg, C., Hamers, T., Kamstra, J. H., Learmont, J. A., Vasquez, B. S., Pierce, G., Ried, B., Patterson, T., Rogan, E., Murphy, S., Addink, M., Hartmann, M. G., Smeenk, C., Dabin, W., Ridoux, V., González, A. F., López, A., Jauniaux, T. & Boon, J. P. (2004). Stereo-isomer specific bioaccumulation of hexabromocyclododecane (HBCD) in marine mammals. Third International Workshop on Brominated Flameretardants (BFR) (2004) pp.411-414.
- Dermal absorption:
Roper, C. S. (2005). The in vitro percutaneous absorption of radiolabelled Hexabromocyclododecane (HBCD) through human skin. Testing laboratory: Inveresk, Tranent, EH33 2NE, Scotland, UK. Report no.: 25031. Owner company: American Chemistry Council, Brominated Flame Retardant Industry Panel, Arlington, VA 22209, USA. Report date: 2005-04-26.
Due to the variety and reliability of information available, a weight of evidence approach was used for this endpoint.

Key value for chemical safety assessment

Additional information

A weight of evidence approach was considered to be appropriate to the Toxicokinetic endpoint due to the reliability and variety of information available. Although most of the investigations presented here were conducted on the registered substance, Scholtz et al, 2002, was conducted on a similar substance, and so the standard read-across protocols were used for this investigation.