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EC number: 700-684-7
CAS number: 80793-17-5
The acute dermal toxicity study was conducted in accordance with OECD 402 (Acute Dermal Toxicity), EU Method B.3 (Acute Toxicity (Dermal)), and EPA OPPTS 870.1200 (Acute Dermal Toxicity) guidelines. AC-6000 was applied dermally to male and female Wistar rats. The test substance was held in place for 24 hrs to an area approximately 10% of the total body surface, after which dressings were removed and residual test substance washed off with tap water. One male was found dead on Day 2. No further mortality occurred. On Days 1 and/or 2 males showed hunched posture, ptosis, chromodacyorrhea and/or flat posture, and two females showed chromodacryorrhea. One male had scabs on the treated skin-area. Changes in body weight were within the range expected for rats used in this type of study, and were not considered indicative of toxicity. There were no macroscopic abnormalities found at necropsy. Therefore, the dermal LD50 of AC-6000 in Wistar rats is >2000 mg/kg body weight.
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