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EC number: 700-684-7
CAS number: 80793-17-5
Skin reactions / irritation
No skin irritation was observed in any of the animals examined.
Macroscopy of the auricular lymph nodes and surrounding area
All nodes of the experimental and control groups were considered normal
in size. no macroscopic abnormalities of the surrounding area were noted.
No significant effects were reported.
Toxicity and mortality
No mortality occurred and no symptoms of systemic toxicity were observed
in the animals of the main study.
skin sensitising properties of AC-6000 were determined in a GLP study
according OECD guideline 429. For this purpose, three groups of five
experimental animals were treated with test substance concentrations of
25%, 50% or 100% on three consecutive days, by open application on the
ears. Five vehicle control (Acetone / Olive oil) animals were similarly
days after the last exposure, all animals were injected with3H-methyl
thymidine and after five hours the draining (auricular) lymph nodes were
excised. After precipitating the DNA of the lymph node cells,
radioactivity measurements were performed. The activity was expressed as
the number of Disintegrations Per Minute (DPM) and a stimulation index
(SI) was subsequently calculated for each group.
skin irritation was observed in any of the animals examined. All nodes
of the experimental and control groups were considered normal in size.
Mean DPM/animal values for the experimental groups treated with test
substance concentrations 25, 50 and 100% were 400, 291 and 264
respectively. The mean DPM/animal value for the vehicle control group
was 226. The SI values calculated for the substance concentrations 25,
50 and 100% were 1.8, 1.3 and 1.2 respectively. There was no indication
that the test substance could elicit an SI ≥ 3 when tested up to 100%.
Based on these results AC-6000 should not be considered a skin
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