Registration Dossier
Registration Dossier
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EC number: 200-823-7 | CAS number: 74-94-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- The Toxicology of the Boranes
- Author:
- Roush G.
- Year:
- 1 959
- Bibliographic source:
- Journal of Occupational Medicine
- Reference Type:
- publication
- Title:
- Summary Report No. 9
- Author:
- Levinskas G.J.
- Year:
- 1 958
- Bibliographic source:
- Graduate School of Public Health, University of Pittsburgh
Materials and methods
Test material
- Reference substance name:
- Dimethylamine-borane (1:1)
- EC Number:
- 200-823-7
- EC Name:
- Dimethylamine-borane (1:1)
- Cas Number:
- 74-94-2
- Molecular formula:
- C2H10BN
- IUPAC Name:
- N-Methylmethanamine-borane (1:1)
Constituent 1
- Specific details on test material used for the study:
- no information provided
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- water
- Controls:
- not specified
- Amount / concentration applied:
- 10% aqueous solution
- Duration of treatment / exposure:
- not specified
- Observation period:
- not specified
- Number of animals:
- not specified
- Details on study design:
- not specified
Results and discussion
In vivo
Results
- Remarks on result:
- other: see box "irritant / corrosive response data"
- Irritant / corrosive response data:
- A 10% aqueous solution of dimethylamine borane produced slight erythema of rabbit skin.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- A 10% aqueous solution of dimethylamine borane produced slight erythema of rabbit skin.
- Executive summary:
In a review publication on the toxicity of boranes, the author cited another publication (Levinskas, 1958) stating that a 10% aqueous solution of dimethylamine-borane produced slight erythema in the rabbit skin. No information on the study design was given and thus based on the limited available information on the methodology this data cannot be used for classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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