Registration Dossier
Registration Dossier
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EC number: 200-823-7 | CAS number: 74-94-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Comparative Toxicity of Boranes
- Author:
- Levinskas G.J.
- Year:
- 1 955
- Bibliographic source:
- American Industrial Hygiene Association Quarterly 16(4), 280-282. DOI: 10.1080/00968205509344339
Materials and methods
- Principles of method if other than guideline:
- No guideline available, study was done before guidelines were published.
- GLP compliance:
- no
- Limit test:
- yes
Test material
- Reference substance name:
- Dimethylamine-borane (1:1)
- EC Number:
- 200-823-7
- EC Name:
- Dimethylamine-borane (1:1)
- Cas Number:
- 74-94-2
- Molecular formula:
- C2H10BN
- IUPAC Name:
- N-Methylmethanamine-borane (1:1)
Constituent 1
- Specific details on test material used for the study:
- - Melting point: 35.5 - 36.0 °C
- Physical state at room temperature: white crystalline solid
Test animals
- Species:
- rat
- Strain:
- other: CFW
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: adult
- Weight at study initiation: 200-280 g
- Animals fasted for 18 hours
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- - 24 hours exposure for calculating LD50
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- Adult rats were dosed at four different levels.
- Statistics:
- The LD50 values were calculated by the moving average method of Thompson.
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 59.2 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no data
- Clinical signs:
- other: no data
- Gross pathology:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- In conclusion, the oral LD50 value in rats after treatment with dimethylamine-borane is determined to be 59.2 mg/kg bw.
- Executive summary:
In an acute oral toxicity study, adult CFW rats (male) were given a single oral dose of dimethylamine-borane. An oral LD50 of 59.2 mg/kg bw has been determined.
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