Registration Dossier
Registration Dossier
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EC number: 200-823-7 | CAS number: 74-94-2
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- The Toxicology of the Boranes
- Author:
- Roush G.
- Year:
- 1 959
- Bibliographic source:
- Journal of Occupational Medicine
Materials and methods
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Dimethylamine-borane (1:1)
- EC Number:
- 200-823-7
- EC Name:
- Dimethylamine-borane (1:1)
- Cas Number:
- 74-94-2
- Molecular formula:
- C2H10BN
- IUPAC Name:
- N-Methylmethanamine-borane (1:1)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Details on exposure:
- not specified
- Doses:
- not specified
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 50 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no data
- Clinical signs:
- The rats showed progressive depression leading to coma and death was apparently respiratory.
- Body weight:
- no data
- Gross pathology:
- no data
Applicant's summary and conclusion
- Conclusions:
- In this review article, the LD50 value in rats after intraperitoneally treatment with dimethylamine-borane was determined to be 50 mg/kg body weight.
- Executive summary:
In an acute toxicity study citied in this review article, groups of rats were given a single intraperitoneal dose of dimethylamine-borane. Based on the mortality, an intraperitoneal LD50 of 50 mg/kg bw was determined. The rats showed progressive depression leading to coma and death was apparently respiratory.
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