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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
20 Oct 2018 to 11 Dec 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
2006
Qualifier:
according to
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Version / remarks:
1996
GLP compliance:
yes (incl. certificate)
Type of method:
gas saturation method
Key result
Temp.:
20 °C
Vapour pressure:
0 Pa
Key result
Temp.:
40 °C
Vapour pressure:
0 Pa

DETERMINATION OF VAPOUR PREESSURE AT 20ºC (40 mL/minute)

Sample Code

(W) Mass of
Evaporated
Test Item (g)

(V) Volume of Saturated
Gas (m3)

(R)
Universal Gas Constant

(J/mol/K)

(T)
Temperature
(K)

(M) Molar Mass of Test Item (g/mol)

(R)*(T)

Vapour
Pressure
(mPa)

Mean
Vapour
Pressure
(mPa)

± SD

Sample C2 R1 -Rep1

2.13E-05

0.6912

8.314

293.15

246.4

2437.25

0.3

0.31

0.008

Sample C2 R1 -Rep2

2.09E-05

0.6912

8.314

293.15

246.4

2437.25

0.3

Sample C2 R2 -Rep1

2.21E-05

0.6912

8.314

293.15

246.4

2437.25

0.32

Sample C2 R2 -Rep2

2.18E-05

0.6912

8.314

293.15

246.4

2437.25

0.31

Sample C2 R3 -Rep1

2.12E-05

0.6912

8.314

293.15

246.4

2437.25

0.3

Sample C2 R3 -Rep2

2.13E-05

0.6912

8.314

293.15

246.4

2437.25

0.3

DETERMINATION OF VAPOUR PREESSURE AT 40ºC (40 mL/minute)

Sample Code

(W) Mass of
Evaporated
Test Item (g)

(V) Volume of Saturated
Gas (m3)

(R)
Universal Gas Constant (J/mol/K)

(T)
Temperature
(K)

(M) Molar Mass of Test Item (g/mol)

(R)*(T)

Vapour
Pressure
(mPa)

Mean
Vapour
Pressure
(mPa)

± SD

Sample C2 R1 -Rep1

2.14E-05

0.6912

8.314

313.15

246.4

2603.53

0.33

0.34

0.013

Sample C2 R1 -Rep2

2.13E-05

0.6912

8.314

313.15

246.4

2603.53

0.33

Sample C2 R2 -Rep1

2.28E-05

0.6912

8.314

313.15

246.4

2603.53

0.35

Sample C2 R2 -Rep2

2.33E-05

0.6912

8.314

313.15

246.4

2603.53

0.36

Sample C2 R3 -Rep1

2.25E-05

0.6912

8.314

313.15

246.4

2603.53

0.34

Sample C2 R3 -Rep2

2.18E-05

0.6912

8.314

313.15

246.4

2603.53

0.33

Conclusions:
The vapour pressure for the test item was determined to be 0.31 mPa at 20ºC and 0.34 mPa at 40ºC.
Executive summary:

The present study was conducted to determine the Vapour pressure of test item by gas saturation method as per OECD guideline for the testing of chemicals, No. 104. Specificity, LOD, LOQ, linearity, accuracy, precision and stability was analysed during this validation of the analytical method and results are within the specified limits. The vapour pressure study was performed by conducting preliminary test and definitive test. During the preliminary test, the test item was exposed to three different flow rates at 20 mL/min, 40 mL/min and 60 mL/min at 40°C to optimize the suitable flow rate. Optimum flow rate selected during preliminary test was used for definitive test and the definitive was conducted at two different temperatures such as 20°C and 40°C. The vapour pressure for the test item was determined to be 0.31 mPa at 20ºC and 0.34 mPa at 40ºC.

Description of key information

The vapour pressure was tested according to the OECD 104 and it was determined to be 3.1E-4 Pa at 20 °C.

Key value for chemical safety assessment

Vapour pressure:
0 Pa
at the temperature of:
20 °C

Additional information