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Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

20 Oct 2018 to 11 Dec 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Version / remarks:

2006

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7950 (Vapor Pressure)

Version / remarks:

1996

GLP compliance:

yes (incl. QA statement)

Type of method:

gas saturation method

Key result

Temp.:

20 °C

Vapour pressure:

0 Pa

Key result

Temp.:

40 °C

Vapour pressure:

0 Pa

DETERMINATION OF VAPOUR PREESSURE AT 20ºC (40 mL/minute)

Sample Code	(W) Mass of Evaporated Test Item (g)	(V) Volume of Saturated Gas (m3)	(R) Universal Gas Constant (J/mol/K)	(T) Temperature (K)	(M) Molar Mass of Test Item (g/mol)	(R)*(T)	Vapour Pressure (mPa)	Mean Vapour Pressure (mPa)	± SD
Sample C2 R1 -Rep1	2.13E-05	0.6912	8.314	293.15	246.4	2437.25	0.3	0.31	0.008
Sample C2 R1 -Rep2	2.09E-05	0.6912	8.314	293.15	246.4	2437.25	0.3
Sample C2 R2 -Rep1	2.21E-05	0.6912	8.314	293.15	246.4	2437.25	0.32
Sample C2 R2 -Rep2	2.18E-05	0.6912	8.314	293.15	246.4	2437.25	0.31
Sample C2 R3 -Rep1	2.12E-05	0.6912	8.314	293.15	246.4	2437.25	0.3
Sample C2 R3 -Rep2	2.13E-05	0.6912	8.314	293.15	246.4	2437.25	0.3

DETERMINATION OF VAPOUR PREESSURE AT 40ºC (40 mL/minute)

Sample Code	(W) Mass of Evaporated Test Item (g)	(V) Volume of Saturated Gas (m3)	(R) Universal Gas Constant (J/mol/K)	(T) Temperature (K)	(M) Molar Mass of Test Item (g/mol)	(R)*(T)	Vapour Pressure (mPa)	Mean Vapour Pressure (mPa)	± SD
Sample C2 R1 -Rep1	2.14E-05	0.6912	8.314	313.15	246.4	2603.53	0.33	0.34	0.013
Sample C2 R1 -Rep2	2.13E-05	0.6912	8.314	313.15	246.4	2603.53	0.33
Sample C2 R2 -Rep1	2.28E-05	0.6912	8.314	313.15	246.4	2603.53	0.35
Sample C2 R2 -Rep2	2.33E-05	0.6912	8.314	313.15	246.4	2603.53	0.36
Sample C2 R3 -Rep1	2.25E-05	0.6912	8.314	313.15	246.4	2603.53	0.34
Sample C2 R3 -Rep2	2.18E-05	0.6912	8.314	313.15	246.4	2603.53	0.33

Conclusions:

The vapour pressure for the test item was determined to be 0.31 mPa at 20ºC and 0.34 mPa at 40ºC.

Executive summary:

The present study was conducted to determine the Vapour pressure of test item by gas saturation method as per OECD guideline for the testing of chemicals, No. 104. Specificity, LOD, LOQ, linearity, accuracy, precision and stability was analysed during this validation of the analytical method and results are within the specified limits. The vapour pressure study was performed by conducting preliminary test and definitive test. During the preliminary test, the test item was exposed to three different flow rates at 20 mL/min, 40 mL/min and 60 mL/min at 40°C to optimize the suitable flow rate. Optimum flow rate selected during preliminary test was used for definitive test and the definitive was conducted at two different temperatures such as 20°C and 40°C. The vapour pressure for the test item was determined to be 0.31 mPa at 20ºC and 0.34 mPa at 40ºC.

Description of key information

The vapour pressure was tested according to the OECD 104 and it was determined to be 3.1E-4 Pa at 20 °C.

Key value for chemical safety assessment

Vapour pressure:

0 Pa

at the temperature of:

20 °C