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Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20 Oct 2018 to 11 Dec 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Version / remarks:
- 2006
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7950 (Vapor Pressure)
- Version / remarks:
- 1996
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- gas saturation method
- Key result
- Temp.:
- 20 °C
- Vapour pressure:
- 0 Pa
- Key result
- Temp.:
- 40 °C
- Vapour pressure:
- 0 Pa
- Conclusions:
- The vapour pressure for the test item was determined to be 0.31 mPa at 20ºC and 0.34 mPa at 40ºC.
- Executive summary:
The present study was conducted to determine the Vapour pressure of test item by gas saturation method as per OECD guideline for the testing of chemicals, No. 104. Specificity, LOD, LOQ, linearity, accuracy, precision and stability was analysed during this validation of the analytical method and results are within the specified limits. The vapour pressure study was performed by conducting preliminary test and definitive test. During the preliminary test, the test item was exposed to three different flow rates at 20 mL/min, 40 mL/min and 60 mL/min at 40°C to optimize the suitable flow rate. Optimum flow rate selected during preliminary test was used for definitive test and the definitive was conducted at two different temperatures such as 20°C and 40°C. The vapour pressure for the test item was determined to be 0.31 mPa at 20ºC and 0.34 mPa at 40ºC.
Reference
DETERMINATION OF VAPOUR PREESSURE AT 20ºC (40 mL/minute)
Sample Code |
(W) Mass of |
(V) Volume of Saturated |
(R) (J/mol/K) |
(T) |
(M) Molar Mass of Test Item (g/mol) |
(R)*(T) |
Vapour |
Mean |
± SD |
Sample C2 R1 -Rep1 |
2.13E-05 |
0.6912 |
8.314 |
293.15 |
246.4 |
2437.25 |
0.3 |
0.31 |
0.008 |
Sample C2 R1 -Rep2 |
2.09E-05 |
0.6912 |
8.314 |
293.15 |
246.4 |
2437.25 |
0.3 |
||
Sample C2 R2 -Rep1 |
2.21E-05 |
0.6912 |
8.314 |
293.15 |
246.4 |
2437.25 |
0.32 |
||
Sample C2 R2 -Rep2 |
2.18E-05 |
0.6912 |
8.314 |
293.15 |
246.4 |
2437.25 |
0.31 |
||
Sample C2 R3 -Rep1 |
2.12E-05 |
0.6912 |
8.314 |
293.15 |
246.4 |
2437.25 |
0.3 |
||
Sample C2 R3 -Rep2 |
2.13E-05 |
0.6912 |
8.314 |
293.15 |
246.4 |
2437.25 |
0.3 |
DETERMINATION OF VAPOUR PREESSURE AT 40ºC (40 mL/minute)
Sample Code |
(W) Mass of |
(V) Volume of Saturated |
(R) |
(T) |
(M) Molar Mass of Test Item (g/mol) |
(R)*(T) |
Vapour |
Mean |
± SD |
Sample C2 R1 -Rep1 |
2.14E-05 |
0.6912 |
8.314 |
313.15 |
246.4 |
2603.53 |
0.33 |
0.34 |
0.013 |
Sample C2 R1 -Rep2 |
2.13E-05 |
0.6912 |
8.314 |
313.15 |
246.4 |
2603.53 |
0.33 |
||
Sample C2 R2 -Rep1 |
2.28E-05 |
0.6912 |
8.314 |
313.15 |
246.4 |
2603.53 |
0.35 |
||
Sample C2 R2 -Rep2 |
2.33E-05 |
0.6912 |
8.314 |
313.15 |
246.4 |
2603.53 |
0.36 |
||
Sample C2 R3 -Rep1 |
2.25E-05 |
0.6912 |
8.314 |
313.15 |
246.4 |
2603.53 |
0.34 |
||
Sample C2 R3 -Rep2 |
2.18E-05 |
0.6912 |
8.314 |
313.15 |
246.4 |
2603.53 |
0.33 |
Description of key information
The vapour pressure was tested according to the OECD 104 and it was determined to be 3.1E-4 Pa at 20 °C.
Key value for chemical safety assessment
- Vapour pressure:
- 0 Pa
- at the temperature of:
- 20 °C
Additional information
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