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Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Reference
Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Qualifier:
no guideline followed
Principles of method if other than guideline:
Descriptors used for the Estimation of Toxicity to Aquatic Organisms Using ECOSAR v2.0
- Water solubility selected: 2.47 mg/L (measured)
- Partition coefficient selected: 5.56 (measured)
- SMILES: CC(=O)C=C(C)C21CC3(C)CCC1C3(C)CCC2
- Molecular weight: 246.4 g/mol
GLP compliance:
no
Key result
Duration:
96 h
Dose descriptor:
EC50
Effect conc.:
0.13 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Key result
Duration:
96 h
Dose descriptor:
other: Chronic Value (ChV)
Effect conc.:
0.18 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Remarks on result:
other: The toxicity value was estimated through application of acute-to-chronic ratios per methods outlined in the ECOSAR Methodology Document

Description of key information

The estimated 96h-EC50 is 0.13 mg/L.

Key value for chemical safety assessment

EC50 for freshwater algae:
0.13 mg/L
EC10 or NOEC for freshwater algae:
0.18 mg/L

Additional information

For the assessment of the aquatic toxicity of the test substance to algae, QSAR results were used. ECOSAR v2.0 was used as the QSAR model and a water solubility of 2.47 mg/L and a partition coefficient of 5.56 was used for the prediction of the acute aquatic toxicity in algae. The results fell within the applicability domain of the QSAR model and subsequently the criteria listed in Annex XI of Regulation (EC) No 1907/2006 chapter 1.3 are considered to be fulfilled. Therefore, other studies on aquatic toxicity in algae are not provided.