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EC number: -
CAS number: -
Determination of the partition
coefficient of the substance
Mean (t0) Thiourea
Mean (tR) Test item
Average log Pow
Sample R1 Rep-1
Sample R1 Rep-2
Sample R2 Rep-1
Sample R2 Rep-2
Partition Coefficient of the test item was determined in accordance with
OECD TG 117. The partition coefficient of the test item was determined
by HPLC-UV method. The retention times of the corresponding standards
and the test item were confirmed by an individual injection by HPLC-UV
method. Standards were injected for five replications and their
corresponding mean retention time for Thiourea, Acetanilide,
Nitrobenzene, Bromobenzene, Benzyl benzoate, Phenanthrene and DDT were
found to be 2.699, 3.368, 4.019, 4.637, 7.087, 7.558 and 18.146 minutes
respectively. The Sample was analyzed for two replications with
duplicate injections for each replication. The corresponding mean
retention times of Thiourea and the test item for replication 1 for
duplicate injections was found to be 2.700 and 17.805. The corresponding
mean retention times of Thiourea and the test item for replication 2 for
duplicate injections was found to be 2.697 and 17.740. Standards
capacity factor k for Thiourea, Acetanilide, Nitrobenzene, Bromobenzene,
Benzyl benzoate, Phenanthrene and DDT were found to be 0.000, 0.248,
0.489, 0.718, 1.626, 1.800 and 5.723 respectively. Sample capacity
factor k for Thiourea and the test item was found to be 0.000 and 5.594
for replication 1 and similarly the capacity factor k for Thiourea and
the test item for replication 2 was found to be 0.000 and 5.578
respectively. The obtained results of log Pow of the test item were
found to be 5.56 and 5.55 for replication 1 and 2 respectively, which is
acceptable and within a range of ± 0.1 logs units. The mean log Pow was
found to be 5.56 with corresponding to an octanol/water partition
coefficient of log Pow ± 0.5 log units. It is concluded that the
partition coefficient log Pow of the test item was determined in HPLC
method and was found to be 5.56.
The partition coefficient is determined to
be 5.56, according to the OECD 117 guideline study.
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