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Ecotoxicological information

Short-term toxicity to fish

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Reference
Endpoint:
short-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
Remarks:
Measured Log Kow is greater than the model's specific cut-off value of 5.0.
Qualifier:
no guideline followed
Principles of method if other than guideline:
Descriptors used for the Estimation of Toxicity to Aquatic Organisms Using ECOSAR v2.0
- Water solubility selected: 2.47 mg/L (measured)
- Partition coefficient selected: 5.56 (measured)
- SMILES: CC(=O)C=C(C)C21CC3(C)CCC1C3(C)CCC2
- Molecular weight: 246.4 g/mol
GLP compliance:
no
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
0.48 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Remarks on result:
other: No effects at saturation are expected for this endpoint
Remarks:
The test substance falls within the applicability domain of the model, however, the measured Log Kow is greater than the model's specific cut-off value of 5.0.

Description of key information

No acute effects in fish at saturation are expected.

Key value for chemical safety assessment

Additional information

For the assessment of the aquatic toxicity of the test substance to fish, QSAR results were used. ECOSAR v2.0 was used as the QSAR model and a water solubility of 2.47 mg/L and a partition coefficient of 5.56 was used for the prediction of the aquatic toxicity in fish. The results fell within the applicability domain of the QSAR model and subsequently the criteria listed in Annex XI of Regulation (EC) No 1907/2006 chapter 1.3 are considered to be fulfilled. Therefore, other studies on aquatic toxicity in fish are not provided. It must be noted that the measured Log Kow is greater than the model's specific cut-off value of 5.0. Therefore, the model expects no effects at saturation to occur for this endpoint.