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EC number: 216-653-1 | CAS number: 1634-04-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, non-guideline study, some restrictions in reporting, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- tert-butyl methyl ether
- EC Number:
- 216-653-1
- EC Name:
- tert-butyl methyl ether
- Cas Number:
- 1634-04-4
- Molecular formula:
- C5H12O
- IUPAC Name:
- 2-methoxy-2-methylpropane
- Details on test material:
- MTBE, X-801-25, 100%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Charles River albino
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The animals had a average body weight of 240 grams.
The animals were housed individually.
The animals were permitted a standard laboratory diet plus water ad libitum.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23-25
- Test atmosphere pressure (inches Hg): 29.90-30.24
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Details on inhalation exposure:
- Exposure was in a Plexiglas inhalation chamber of 70 liters. The chamber was designed so that the animals could be introduced to the test atmosphere after 99 percent of the desired vapour concentration was established.
Vapour was generated by bubbling a stream of clean dry air through the undiluted test material. The resulting air-vapour stream was then introduced into the exposure chamber at the top center, dispersed by a baffle plate and exhausted at the bottom of the chamber.
Average nominal vapour generation were calculated by dividing the total weight of test material vaporized by the total volume of air used during each inhalation exposure. - Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Concentrations:
- 44, 65, 86, 99, 167 and 395 mg/l
- No. of animals per sex per dose:
- 5/sex/dose
- Control animals:
- not specified
- Details on study design:
- Each experiment was designed to run for a four-hour period during which time observations were made with respect to incidence of mortality and reactions displayed. At the end of the exposure period, the rats were returned to their stock cages and observed for the following 14 days.
A body weight was determined for each animal at the end of the 14-day observation period. Gross pathologic examinations were scheduled to be conducted upon all animals which might succumb during the test period as well as those sacrificed at the end of the 14 day observation period. - Statistics:
- The LC50 was calculated using the techniques of Litchfield and Wilcoxon.
For analysis of the effects, no details were reported.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 85 mg/L air
- 95% CL:
- > 79 - < 91
- Exp. duration:
- 4 h
- Mortality:
- In the 86 mg/l group, six animals died and in the higher dose groups, all animals died. In the 86 mg/l concentration group, the time of death varied from 110 to 225 minutes after the start of exposure, in the 99 mg/l concentration group, the time of death varied from 96-240 minutes, in the 167 mg/l concentration group, the time of death varied from 59-80 minutes and in the high dose group, the time was 25-51 minutes.
- Clinical signs:
- other: The clinical signs included ataxia, tremors, lacrimation, clonia, unconsciousness and hyperactivity. Surviving animals appeared normal the morning after exposure.
- Body weight:
- No adverse effects were observed.
- Gross pathology:
- Necropsy of the animals which died revealed slight to moderate hyperemia in the lungs. The animals that survived the 14-day observation period had minimal to mild lung hyperemia.
Applicant's summary and conclusion
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