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EC number: 216-653-1 | CAS number: 1634-04-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Detailed account of vapour test atmosphere generation methodology used for toxicity studies of gasoline and gasoline/oxygenate mixtures (including gasoline-MTBE), with extensive chemical analysis). Study in itself reliable, but of questionable relevance to toxicity assessment of MTBE.
Data source
Reference
- Reference Type:
- publication
- Title:
- Health assessment of gasoline and fuel oxygenate vapors: Generation and characterization of test materials
- Author:
- Henley M et al
- Year:
- 2 014
- Bibliographic source:
- Regulatory Toxicology and Pharmacology 70 (2014) S13–S17
Materials and methods
- Type of study / information:
- Description of test vapours produced from baseline gasoline and gasoline with added oxygenate (including gasoline + MTBE): methods used to generate vapours, collect vapour condensates and regenerate vapours used in various toxicological studies. Includes analytical characterisation of the vapour condensates.
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Development of methods for vapour generation compatible with specific EPA requirements (211b rule at CFR 79.57(f)(2)) but modified from that to permit safe and reproducible conditiond on testing laboratories
- GLP compliance:
- no
- Remarks:
- Not generally applicable, but GLP-compliant analyses included
Test material
- Reference substance name:
- Baseline gasoline (BG)
- IUPAC Name:
- Baseline gasoline (BG)
- Reference substance name:
- Gasoline + MTBE (BG+MTBE)
- IUPAC Name:
- Gasoline + MTBE (BG+MTBE)
- Reference substance name:
- Gasoline + other oxygenates also investigated: not further described here
- IUPAC Name:
- Gasoline + other oxygenates also investigated: not further described here
- Test material form:
- other: Vapours collected as condensates
- Details on test material:
- BG = Reformulated gasoline summer baseline fuel meeting CAA section 211(k)(10)(B)(i) specification (40 CFR 79.55)
BGVC = vapour condensate collected from BG
BG+MTBE = BG with MTBE added to create 2.7 wt% O2 content (corresponding to 14.9 vol% MTBE)
G/MTBE = vapour condensate from BG+MTBE
Constituent 1
Constituent 2
Constituent 3
Results and discussion
Any other information on results incl. tables
Collected vapour condensates represented 16 vol% (BGVC) or 17 vol% (G/MTBE) of the initial liquids (BG or BG+MTBE respectively). Analysis of equilibrium vapour in headspace above BG+MTBE heated to 130F/54C in 20 ml vials indicated an MTBE vapour content of 19.3% (GC-FID, Chevron SE-30 analysis): using this as a target, MTBE vapour content of 21.3 vol% was measured during the large-scale generation of G+MTBE vapour for test article (G/MTBE vapour condensate) collection, using a slightly different GC-FID method under GLP.
Similarity of baseline gasoline vapour condensate to vapour above heated gasoline.
Carbon number component |
Liquid gasoline |
Equilibrium vapour above gasoline at 130F/54C (vol%) |
BGVC condensate (vol%) |
C3 |
0 |
0 |
0.1 |
C4 |
4.7 |
27.1 |
20.6 |
C5 |
16.3 |
40.9 |
46.4 |
C6 |
18.5 |
18.8 |
21.6 |
C7 |
19.1 |
8.0 |
9.0 |
C8 |
20.2 |
4.0 |
2.2 |
C9 |
10.6 |
0.8 |
0.2 |
C10 |
6.0 |
0.2 |
0 |
C11 |
2.8 |
0 |
0 |
C12 |
1.8 |
00.1 |
0 |
GC-FID analysis using proprietary (Chevron SE-30) analysis
Applicant's summary and conclusion
- Conclusions:
- A large-scale procedure for generation of vapours and collection of vapour condensates from gasoline alone and gasoline with added oxygenates (including MTBE) was developed and described. Composition of the vapour condensate so collected from gasoline was shown to be similar to that of equilibrium vapour above heated liquid gasoline.
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