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Toxicological information

Toxicity to reproduction: other studies

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Administrative data

Endpoint:
toxicity to reproduction: other studies
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only an abstract is available.

Data source

Reference
Reference Type:
publication
Title:
Methyl Tertiary-Butyl Ether Induces Alterations In Mouse Testis Weight, Testosterone Production And Morphology.
Author:
Almeida L, Hall E
Year:
2004
Bibliographic source:
Toxicologist; 78(1-S):188

Materials and methods

Principles of method if other than guideline:
Subacute exposure via drinking water to study effects on male gonads
GLP compliance:
not specified
Type of method:
in vivo

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
mouse
Strain:
Balb/c
Sex:
male

Administration / exposure

Route of administration:
oral: drinking water
Vehicle:
unchanged (no vehicle)
Duration of treatment / exposure:
28 days
Frequency of treatment:
continuously
Doses / concentrations
Remarks:
Doses / Concentrations:
80, 800, and 8000 ppb
Basis:
other: concentration in drinking water
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levels

Dose descriptor:
NOAEL
Effect level:
80 other: ppb
Sex:
male
Basis for effect level:
other: A significant, dose-dependent increase in mean combined testis weight, mean seminal vesicle weight, mean seminiferous tubule diameter, and incidence of abnormal tubules. Serum testosterone was substantially decreased by exposure to 800 and 8000 ppb.

Observed effects

These results indicate that MTBE may act via a disruption in endocrine-mediated Leydig cell testosterone production.

Any other information on results incl. tables

Regarding the Almeida reported findings, a recent study by de Peyster et al. (2008)** which was conducted using the same protocol did not replicate the findings reported by Almeida.

 

** De Peyster, A, Rodriguez, Y, Shuto, R, Goldberg, B, Gonzales, F, Pu, X, Klaunig, JE. (2008). Effect of oral methyl-t-butyl ether (MTBE) on the male mouse reproductive tract and oxidative stress in liver. Reproductive Toxicology 26(3-4): 246-53.

Applicant's summary and conclusion