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EC number: 216-653-1
CAS number: 1634-04-4
studies with guinea pigs were available for assessment. In a
Magnusson-Kligman maximisation test (equivalent or similar to OECD
guideline 406), 1% MTBE-water solution was used for induction
intracutaneously (Inveresk Research International, 1979b). One week
later, an occlusive topical induction was performed with 1% MTBE-water
solution. The topical induction phase lasted 48 hours. After a pre-test
with various challenge concentrations, the animals were challenged
topically with a 1% MTBE-water solution 14 days after the epicutaneous
induction. No skin sensitisation was reported.
In the other
study, ten guinea pigs were induced with an initial induction of 0.5 ml
MTBE in saline. Every second day for the next three weeks, the animals
received an intradermal injection of 0.1 ml MTBE in saline for a total
of ten injections. (Litton Bionetics Inc., 1980a; ARCO Chemical Company,
1980). Fifteen days after the last injection, the guinea pigs received
an intracutaneous challenge injection (0.05 ml of 0.1% solution of MTBE)
below the sensitisation site. Skin reactions in the MTBE-group varied
from slight to well defined erythema with occasional oedema. MTBE was
not considered sensitising.
accordance with EU Classification, Labelling and Packaging of Substances
and Mixtures (CLP) Regulation (EC) No. 1272/2008,
classification is not necessary for sensitisation.
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