Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 216-653-1 | CAS number: 1634-04-4
Toxicity to other aquatic organisms
Administrative data
Link to relevant study record(s)
Description of key information
An abstract is available in the public literature on a study exposing tadpoles (Rana temporaria) to nominal concentrations of MTBE in the range 100 to 10,000 mg/l.
Additional information
Tadpoles (Rana temporaria) were exposed to nominal concentrations of MTBE in the range 100 to 10,000 mg/l. The 48-h LC50 under these conditions was 2500 mg/l, with concentrations of up to 2000 mg/l without any lethal effect. Exposure to lower levels (100 mg/l) led to a marked weight increase of tadpoles and frogs that had undergone metamorphosis. At this concentration, metamorphosis was stimulated, occurring two days earlier than in controls.
The normal time from hatching to metamorphosis of Rana temporaria is commonly 30-45 days (Loman, 1999), but may show even more plasticity, e.g., 20-60 days, temperature being the most important variable (Merilä et al., 2000).
Although any deviation from the normal is usually considered adverse, this is not so in this case. Larvae tend to concentrate into large schools in shallow water where their density sometimes reaches 100 individuals per liter. Crowding effect is typical for such tadpole aggregations, and the sizes of metamorphosed juveniles are variable. Larger juveniles usually metamorphosed first. These have higher survival rates during their first over-wintering, which emphasizes an advantage of early metamorphosis.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
