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EC number: 216-653-1
CAS number: 1634-04-4
The most critical 96-h LC50 is 672 mg/l in the freshwater fish Pimephales promelas. For marine fish the most critical value was the 96-h LC50 574 mg/l in the marine fish Menidia beryllina.
There are several guideline studies available, both for freshwater and
marine fish. The studies are either semi-static or flow-through and the
test concentrations are measured in all studies. The most critical
studies for both freshwater and marine species were therefore chosen as
key studies. For freshwater fish the most critical effect concentration
is a 96-h LC50 value of 672 mg/l in fathead minnow (Pimephales
promelas) (Geiger et al., 1988). The most critical effect
concentration in marine fish is a 96-h LC50 of 574 mg/l in inland
silverside (Menidia beryllina) (BenKinney et al., 1994). These
values will be used in the assessment.
A NOEC of 220mg/l and an LC50 of ~1700mg/l was established for a 5 day
embryo/sac fry study in zebrafish (Danio rerio) examining
developmental and other end points including gene expression (Bonventre
et al., 2011, 2012). However, the study greatly exceeds max. test
concentration recommended in the OECD 212 test guideline and has limited
relevance for the environmental risk assessment.
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