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EC number: 216-653-1
CAS number: 1634-04-4
Formation of the other MTBE metabolites
involves further biotransformation of TBA formed in the first step of
metabolic pathway. Conjugation of TBA with activated glucuronic acid
results in excretion of the glucuronide conjugate. The two other
metabolites (2-methyl-1,2-propanediol and 2-hydroxyisobutyrate) present
in urine of TBA-treated animals and also in urine of rats exposed to
MTBE suggest further oxidative metabolism of the intermediate metabolite
TBA. The likely pathway for formation of these metabolites involves
oxidation of TBA by CYP to give 2-methyl-1,2-propanediol. TBA is not a
substrate for alcohol dehydrogenase, but it is oxidized by rat liver
microsomes to formaldehyde and acetone under conditions consistent with
an involvement of CYP (Cederbaum and Cohen 1980, Cederbaum et al 1983).
CYPmediated oxidation of a C–H bond in one of the methyl groups of TBA
results in excretion of the diol metabolite. Further oxidation of
2-methyl-1,2-propanediol results in 2-hydroxyisobutyrate, which is
excreted as a major metabolite of TBA, as well as of MTBE.
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