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EC number: 216-653-1
CAS number: 1634-04-4
The most critical 48-h EC50 is 472 mg/l in Daphnia magna. For marine invertebrates the most critical toxicity value was the harmonised 96-h LC50 of106 mg/l in Americamysis bahia.
There are several
studies available both for freshwater and marine invertebrates, most of
which are guideline studies.
results obtained with Daphnia
most critical value for this species(48
hr EC50, 472 mg/l) chosen
as the key study (Wildlife International Ltd., 1999c).
species the effect concentrations range from 44 mg/l for mysid shrimp (Americamysis
bahia) to 306 mg/l for blue crab (Callinectes sapidus).
Results from several studies indicate that the mysid shrimp is the most
sensitive marine species, but the results from the different are
inconsistent. In one semi-static GLP-compliant near guideline study, in
which the MTBE concentrations were not monitored the 96-h LC50 was 44
mg/l (T. R. Wilbury Laboratories, Inc., 1994). In a second semi-static
EPA OPPTS 850.1035 study, with analytical monitoring, the observed 96-h
LC50 was 136 mg/l (BennKinney et al., 1994). A third semi-static
GLP-compliant EPA OPPTS 850.1035 study, with analytical monitoring,
reported a 96-h LC50 of 200 mg/l and a 96-EC50 of 187 mg/l based on
erratic swimming (Rausina et al., 2002).
study by T. R. Wilbury Laboratories, Inc. (1994) with the available 28-d
NOEC of the same species of 26 mg/l, it can be concluded that the effect
in the short-term test is higher than in the long-term test. The study
is well reported and executed and apart from the lack of analytical
monitoring no deviations from standard guidelines (e. g. EPA OPPTS
850.1035) were observed and no explanation could be found why the
results are inconsistent with those from other studies.
technical reason is apparent to explain these differences, and since the
results from the three studies are less than one order of magnitude
apart, the results were harmonised by a geometric mean. The resultant
96-h LC50 of 106 mg/l in mysid shrimp (Americamysis bahia) and
the 48-h EC50 of 472 mg/l in Daphnia magna will be used in the
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