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EC number: 231-847-6
CAS number: 7758-98-7
Materials and Methods
The test substance article, copper II sulphate pentahydrate, was
evaluated for it's potential to produce primary dermal irritation after
a single topical 4 -hour application to the skin of rabbits at dose of
0.5 g. The design was in accordance with OECD 404 (1981), EEC 92/69 -
Annex V - Method B4 (1992).
Results and Discussion
Clinical: a weak irritation with points of burnt appearance was provoked
in one animal.
Mean values for cutaneous irritation were 0.22 for erythema and 0 for
The lesions observed at 72 hours showed good reversibility at day 7.
The test substance is considered non-irritating to the skin of rabbits
in accordance with the guidelines.
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