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EC number: 231-847-6
CAS number: 7758-98-7
Materials and Methods
Fasted male and female rats were dosed at 447, 562, 708 and 893 mg/kg by
oral gavage administration of the test material, copper II pentahydrate
solution. Clinical signs and body weights were observed over 14 days
post-dose and all animals were subjected to a necropsy.
Mortalities at the 447, 562, 708 and 892 mg/kg treatment groups were 40,
70, 90 and 100% respectively.
Clinical signs observed included lethargy, prostrate posture, green
coloured diarrhoea, voiding few faeces and moribundity.
All decedents died within 1 - 24 hours after dosing.
and female rats combined):
482 mg/kg (95% confidence limits of 403 to 575 mg/kg) by Bliss method
481 mg/kg (95% confidence limits of 400 to 580 mg/kg) by Litchfield &
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