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EC number: 231-847-6
CAS number: 7758-98-7
A range of studies are available that relate to copper toxicity towards amphibians. Only nominal NOECs/EC50 values are available and these were therefore not used for the PNEC derivation.
Almost all tests gathered from literature on
the effect of copper towards amphibians were performed on early life
stages, in laboratory water (with lowDOCconcentration),
with 4 days exposure times and according to standard guidelines. The
results clearly show that amphibians (data were found for Xenopus
laevis, Rana pipiens, Rana ridibunda, Rana hexadactyla, Rana
Sphenocephala and Rana tigrina) are not sensitive towards
copper. Indeed LC50 and NOEC/(L(E) C10 values respectively between 39
and 1,250 µg/l and between 40 and 100,000 µg/l were found.
Most of the studies report however EC50
values and test concentrations were not measured and therefore the
data-reliability is low. These data were therefore not retained for the
Fort et al., 2000 determined optimal copper
concentration ranges for the early life stages of the amphibiaX.
Laevis: 1 to 10 µg Cu/L. Copper
deficiency was observed at copper concentrations < 1 µg Cu/L.
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