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EC number: 231-847-6
CAS number: 7758-98-7
Materials and Methods
Pregnant rabbits received 0, 7.5, 15 or 30 mg Cu/kg bw/day as copper
hydroxide by gavage during day 7 to 28 of gestation. The animals were
sacrificed on day 29 of gestation and the uterine contents were examined
and described. The study was designed as a pilot study to assess the
potential maternal and developmental toxicity of copper hydroxide.
Results and Discussion
Under the conditions of this study, no treatment-related maternal
toxicity was observed at 7.5 mg Cu/kg bw/day and no treatment-related
developmental toxicity occurred at 7.5 and 15 mg Cu/kg bw/day. Observed
effects at the 30 mg/kg/day dose level included maternal mortality, and
gastric ulcer, haemolytic anaemia and renal damage upon necropsy.
Reduced mean foetal weights, slightly increased resorptions and
increased malformations were observed at this dose level. In addition,
reductions of maternal food consumption and body weights were noted at
15 and 30 mg Cu/kg bw/day.
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