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EC number: 215-572-9
CAS number: 1332-65-6
Materials and Methods
Copper II sulphate pentahydrate
was assayed for mutation in 5-histaidine requiring strains (TA98, TA100,
TA1537 and TA102) of Salmonella typhimurium, both in the presence and
absence of metabolic activation by Aroclor 1254 -induced rat liver
post-mitochondrial fraction (S-9) in 2 separate experiments. Following
a range finding study, two experiments were carried out with
concentrations of 1.6, 8, 40, 200 and 1000 µg/l in experiment one and
50, 100, 200, 400 and 800 µg/l in experiment two. The tests were
carried out in triplicate. Both positive and negative controls were
The study complied with the
following guidelines and was conducted in accordance with GLP:
OECD Guidelines 471
EC Directive 2000/32 Annex V Test B14
Results and discussion
None of the dose concentrations
in any of the test strains in either the absence or presence of S-9
resulted in an increase in revertant numbers that were statistically
significant at the 1% level when analysed using a Dunnett’s test. It
was therefore concluded that copper II sulphate pentahydrate was unable
to induce mutation in 5 strains ofS. typhimurium, when tested at
concentrations extending to the toxic range, in both the absence and
presence of rat liver metabolic activation system.
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