Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 215-572-9
CAS number: 1332-65-6
Materials and Methods
Copper II sulphate pentahydrate
was assayed for mutation in 5-histaidine requiring strains (TA98, TA100,
TA1537 and TA102) of Salmonella typhimurium, both in the presence and
absence of metabolic activation by Aroclor 1254 -induced rat liver
post-mitochondrial fraction (S-9) in 2 separate experiments. Following
a range finding study, two experiments were carried out with
concentrations of 1.6, 8, 40, 200 and 1000 µg/l in experiment one and
50, 100, 200, 400 and 800 µg/l in experiment two. The tests were
carried out in triplicate. Both positive and negative controls were
The study complied with the
following guidelines and was conducted in accordance with GLP:
OECD Guidelines 471
EC Directive 2000/32 Annex V Test B14
Results and discussion
None of the dose concentrations
in any of the test strains in either the absence or presence of S-9
resulted in an increase in revertant numbers that were statistically
significant at the 1% level when analysed using a Dunnett’s test. It
was therefore concluded that copper II sulphate pentahydrate was unable
to induce mutation in 5 strains ofS. typhimurium, when tested at
concentrations extending to the toxic range, in both the absence and
presence of rat liver metabolic activation system.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again