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EC number: 215-572-9
CAS number: 1332-65-6
Following intra-dermal injection at induction, all ten test group
animals showed moderate confluent erythema. Since the selected
concentration for the topical induction application was non-irritating
in the preliminary screen, the animals were pre-treated with sodium
lauryl sulphate to induce a mild irritation response in the topical
induction phase. There were no treatment-related mortalities and no
toxic symptoms observed during the induction or challenge phases. Body
weight gains were not affected by treatment.
There were no reactions at the vehicle application sites throughout the
Following the challenge application there were no skin reactions at any
site treated with 50% dicopper chloride trihydroxide suspension in water
A GLP-compliant guinea-pig maximisation test was carried out in
accordance with the requirements of OECD Guideline 406 and EC Method B.6
without significant deviation. Groups of 10 test and 5 control animals
were used. 21 days after the initial intra-dermal
induction exposure to dicopper chloride trihydroxide or the vehicle, the
animals were subjected to a 24 hour challenge exposure with the test
article under an occlusive dressing at a concentration of 50% v/v in
water for injection. Sensitisation responses to the
challenge procedure were evaluated 24 and 48 hours after the end of the
No skin reactions were observed in the main study in any of the test
animals or control animals. On this basis, dicopper chloride
trihydroxide is not classified as a skin sensitiser.
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