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EC number: 215-572-9
CAS number: 1332-65-6
Table 1. summary of individual and mean skin irritation scores
according to Draize
Scores according to Draize for animal number
Mean score per animal 24 - 72 hours
Mean score all animals 24 -72 hours
Mean score all animals 24 - 72 hours
A GLP-compliant study was conducted in accordance with the requirements
of EC Guideline B.4, OECD 404 and US
EPA 40 CFR Section 798.4470 without significant deviation. Dicopper
chloride trihydroxide was moistened with distilled water prior to
application. Six female New Zealand white rabbits
weighing 2.156 to 2.829 kg were acclimatised prior to dosing. On
the day prior to application, an area approximately 10 x 15 cm on the
dorsal area of the trunk of each animal was clipped free of fur. On
the day of application, 0.5 g of test material moistened with 0.5 mL
distilled water was applied to the intact skin on the left side of each
rabbit on a gauze patch. The patch was held in place
by a waterproof plaster wrapped around the trunk. The
right side of each animal was treated in the same way with a patch with
0.5 mL of distilled water only. Elizabethan
collars were fitted to all animals. After 4 hours, the
dressings were removed and the treated sites gently washed to remove any
residual test substance. Animals were examined for
signs of irritation after 30 and 60 minutes, and after 24, 48 and
72 hours, and effects scored according to Draize.
Following application of dicopper chloride trihydroxide, slight erythema
(score 1) was noted in one animal after 30 minutes, and in two animals
after 1 and 24 hours. No erythema was recorded
after 48 or 72 hours. The mean score across all
animals (24 to 72 hours) was 0.1. No oedema was
recorded. Dicopper chloride oxychloride is not
classified as a skin irritant.
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