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EC number: 215-572-9
CAS number: 1332-65-6
A GLP-compliant study was carried out in accordance with the
requirements of EU Guideline B.3 and OECD 402 without significant
deviation. Dicopper chloride trihydroxide was
moistened with Ampuwa prior to application. Five male
and five female Crl:(WI)BR-Wistar rats weighing 181 to 187 g (males) and
161 to 189 g (females) were used. The rats were
acclimatised prior to dosing. A dose level of
2000 mg/kg bw (based on a range finding study) was applied with a gauze
pad to an area of approximately 8 x 4 cm of intact shorn skin, on each
rat on Day 1. The treated area was covered with
gauze and the bodies of the treated animals were wrapped with an
adhesive bandage. After 24 hours, the dressing and any
remaining test substance were removed. Animals were
observed frequently for treatment-related clinical signs on the
treatment day and then daily for the 14‑day post-dosing period. Skin
reactions were recorded daily from Day 2. Animals were
weighed prior to treatment and after 7 days (Day 8) and 14 days (Day 15). Decedents
and animals surviving to 14 days were subject to gross necropsy.
There were no mortalities and no clinical signs of toxicity or skin
reactions throughout the observation period. All
animals showed expected weight gain during the study. No
gross findings were recorded upon necropsy.
The acute dermal LD50 of dicopper chloride trihydroxide to the rat was
greater than 2000 mg/kg bw for males and females. Dicopper
chloride trihydroxide is not classified.
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