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EC number: 215-572-9
CAS number: 1332-65-6
Table 1. Summary of individual and mean eye irritation scores
according to Draize
Scores according to Draize for animal number
Mean score per animala
Mean score all animalsa
a Mean scores after 24, 48 and 72 hours (shaded).
A GLP-compliant study was conducted in accordance with EC
Guideline B.5, OECD 405 and EPA 40 CFR Section 798.4500 without
significant deviation. Dicopper chloride trihydroxide was used for the
study. Six female New Zealand white rabbits weighing 2.240 to 2.595 kg
were acclimatised prior to dosing. 0.1 g of the test substance was
applied to the corneal surface of the right eye of each rabbit and the
eyelids held together for one or two seconds before release. After
24 hours, the treated eyes were flushed with lukewarm water. Animals
were examined for signs of eye irritation after 1, 24, 48 and 72 hours
and 7, 14 and 21 days after administration as appropriate, and
irritation scored according to Draize.
Dicopper chloride trihydroxide caused cornea opacity (up to score
2), iris lesion (up to score 1), conjunctival redness (up to score 3)
and chemosis (up to score 4) of the eyes in all animals at one or more
assessment times. Effects persisted in one or more animals for up to 14
days (cornea opacity) or 72 hours (iris lesion, conjunctival redness,
The mean eye irritation scores recorded in 2/3 of test animals
(i.e. 4 animals) at 24, 48 and 72 hours were <= 1 (cornea opacity and
iris lesion), <= 2 (conjunctival redness and chemosis). On this basis,
dicopper chloride trihydroxide is not classified as irritating to eyes.
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