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EC number: 215-572-9
CAS number: 1332-65-6
Table 1. Summary of individual and mean eye irritation scores
according to Draize
Scores according to Draize for animal number
Mean score per animala
Mean scorefor three animalsa
a Mean scores after 24, 48 and 72 hours (shaded).
A GLP-compliant study was conducted in accordance with the
requirements of EC Guideline B.5 and OECD 405 withoit significant
deviation. Dicopper chloride trihydroxide was used for the study. Three
male New Zealand white rabbits weighing 2.28 to 2.33 kg were
acclimatised prior to dosing. 0.1 g of the test substance was applied
into the conjunctival sac of the right eye of each rabbit and the
eyelids held together for one or two seconds before release. Animals
were examined for signs of eye irritation after 1, 24, 48 and 72 hours
and 4, 5 and 6 days as appropriate, and irritation scored according to
Dicopper chloride trihydroxide caused slight iris lesion and
conjunctival redness (up to score 1) of the eyes in some animals at one
or more assessment times. Effects persisted for up to 72 hours (iris
lesion) or 5 days (conjunctival redness). No cornea opacity at any time
or conjunctival chemosis from Day 2 was recorded.
The mean eye irritation scores recorded in 2/3 of test animals at
24, 48 and 72 hours were <= 1 (cornea opacity and iris lesion) and <= 2
(conjunctival redness and chemosis). On this basis dicopper chloride
trihydroxide is not classified as irritating to eyes.
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