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Environmental fate & pathways

Hydrolysis

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Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Similar to OECD-guideline, GLP.

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1990
Report Date:
1990
Reference Type:
secondary source
Title:
European Union - Risk Assessment Report on Methyl methacrylate
Author:
European Chemicals Bureau
Year:
2002
Bibliographic source:
European Union - Risk Assessment Report, Vol. 22

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
EPA OTS 796.3500 (Hydrolysis as a Function of pH at 25°C)
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Radiolabelling:
yes

Study design

Analytical monitoring:
yes
Buffers:
PREPARATION OF BUFFERS
1) pH 3.0 - Prepared 500 mL of 0.01 M potassium hydrogen phthalate and adjusted pH to 3.00 ± 0.05 with 0.01 N hydrochloric acid. Diluted to 1000 mL with HPLC grade water.
2) pH 7.0 - Prepared 500 mL of 0.01 M potassium dihydrogen phosphate and adjusted pH to 7.00 ± 0.05 with 0.01 N sodium hydroxide. Diluted to 1000 mL with HPLC grade water.
3) pH 11.0 - Prepared 500 mL of 0.005 M sodium bicarbonate and adjusted pH to 11.00 ± 0.05 with 0.01 N sodium hydroxide. Diluted to 1000 mL with HPLC grade water.
Duration of testopen allclose all
Duration:
28 d
pH:
3
Initial conc. measured:
10 mg/L
Duration:
28 d
pH:
7
Initial conc. measured:
10 mg/L
Duration:
28 d
pH:
11
Initial conc. measured:
10 mg/L
Number of replicates:
Three vials for each pH.

Results and discussion

Dissipation DT50 of parent compoundopen allclose all
pH:
7
Temp.:
25 °C
DT50:
53 mo
pH:
11
Temp.:
25 °C
DT50:
2.4 h

Any other information on results incl. tables

At pH 3, 14C-methyl methacrylate was stable to hydrolysis.

Applicant's summary and conclusion

Conclusions:
In a valid guideline study, the hydrolysis half-life of MMA at pH 7 and 25 C was 53 months.
Executive summary:

In a valid guideline study, the hydrolysis half-life of MMA at pH 7 and 25 C was 53 months.