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Toxicological information

Neurotoxicity

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Description of key information

Key value for chemical safety assessment

Additional information

There are a number of findings which may indicate an effect on the nervous system. In oral subchronic rat and mice studies (Batelle 1980, see IUCLID chapter 7.5.3), effects on behaviour (listlessness, locomotoric activity, learning ability, gait and rear leg function), and changes in brain chemistry and peripheral nervous system were observed. Malacia and gliosis of the brain occurred at doses >4 .1 mg/l (equivalent to >1,000 ppm) in rats which inhaled methyl methacrylate vapour for 14 weeks.

However, these neurotoxic effects occurred only at very high concentrations were not seen in the chronic inhalation studies up to concentrations of 500 ppm and are, hence, not relevant for the CSA.

Justification for classification or non-classification

While narcotic effects might occur at concentrations approaching acute lethality, the primary hazard occurring at much lower and more relevant concentrations is irritancy to the respiratory tract.

Hence, no classification is proposed for neurotoxic effects.