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Category name:
Basic Short Chain Alkyl Methacrylates

Justifications and discussions

Category definition:
chemical category name: Basic short chain alkyl methacrylates
Category rationale:
- category applicability domain: set of inclusion and/or exclusion rules
- category justification: Due to trends observed in environmental toxicity, distribution and fate, mammalian ADME (adsorption, distribution, metabolism and excretion), and toxicology between basic short chain (C2-C8) unsaturated linear and branched alkyl methacrylates, a category approach was used for these compounds. The category is defined as methacrylate esters of straight and branched C2 to C8 alcohols. The basic short chain (C2-C8) unsaturated linear and branched alkyl methacrylates included in this category show structure activity relationship with respect to environmental toxicity, distribution and fate, and mammalian toxicity. These esters are rapidly metabolized to methacrylic acid (CAS: 79-41-4) and the structurally corresponding alcohol by non-specific carboxylesterases in several tissues. Methyl methacrylate (MMA) (CAS: 80-62-6), the C1 ester, is the largest volume methacrylate ester that has been studied extensively and reviewed in the OECD HPV Chemical Program. As such MMA provides a robust reference chemical for this category.