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Toxicological information

Toxicity to reproduction

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Administrative data

Endpoint:
toxicity to reproduction
Remarks:
other: dominant lethal assay
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Does not meet criteria of current guidelines

Data source

Reference
Title:
Unnamed
Year:
1976

Materials and methods

Principles of method if other than guideline:
other: dominant lethal assay
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed

Test animals

Species:
mouse
Strain:
CD-1
Sex:
male

Administration / exposure

Route of administration:
inhalation
Duration of treatment / exposure:
Exposure period: 5 days
Premating exposure period (males): 5 days
Premating exposure period (females): no
Duration of test: 8 weeks
Frequency of treatment:
6 hours per day
Doses / concentrations
Remarks:
Doses / Concentrations:
100, 1000, 9000 ppm
Basis:

No. of animals per sex per dose:
14-16 animals per group
Details on study design:
Each male was mated with 2 different unexposed female mice weekly over a period of 8 wk.

Results and discussion

Results: F1 generation

Details on results (F1)

There were no significant differences in fertility of the treated males or survival rate, total implants and early or late post-implantation death in the offspring of treated males compared to controls.

Overall reproductive toxicity

Reproductive effects observed:
not specified

Applicant's summary and conclusion