Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
201-297-1
CAS no.:
80-62-6
Index number:
Molecular formula:
C5H8O2
SMILES:
COC(=O)C(C)=C
InChI:
InChI=1S/C5H8O2/c1-4(2)5(6)7-3/h1H2,2-3H3
Type of substance:
Origin:
Registered compositions:
23
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance is a highly flammable liquid and vapour, causes skin irritation, may cause an allergic skin reaction and may cause respiratory irritation.

Breakdown of all 4431 C&L notifications submitted to ECHA

Flam. Liq. 2 H225 Harmonised Classification
Skin Irrit. 2 H315 Harmonised Classification
STOT SE 3 H335 Harmonised Classification
Skin Sens. 1 H317 Harmonised Classification
STOT SE 3 H370
Skin Sens. 1B H317
Acute Tox. 3 H301
STOT RE 1 H372
Acute Tox. 4 H302
Eye Irrit. 2 H319
Repr. 2 H361
Aquatic Chronic 3 H412
Resp. Sens. 1 H334
Not Classified
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • Ss
Officially recognised in the EU as Skin sensitising ( Harmonised C&L).
  • Ss
There is broad agreement in that a majority of data submitters agree this substance is Skin sensitising (100% of REACH registrations).

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 143 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Substance included in the Community Rolling Action Plan (CoRAP).
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 100 000 - 1 000 000 tonnes per year.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: adhesives and sealants.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

This substance is used in the following activities or processes at workplace: production of mixtures or articles by tabletting, compression, extrusion or pelletisation, the low energy manipulation of substances bound in materials or articles, open transfer and processing with minerals/metals at elevated temperature and high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding).

Other release to the environment of this substance is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

This substance can be found in complex articles, with no release intended: electrical batteries and accumulators, vehicles and machinery, mechanical appliances and electrical/electronic products (e.g. computers, cameras, lamps, refrigerators, washing machines). This substance can be found in products with material based on: leather (e.g. gloves, shoes, purses, furniture), plastic (e.g. food packaging and storage, toys, mobile phones), fabrics, textiles and apparel (e.g. clothing, mattress, curtains or carpets, textile toys), paper (e.g. tissues, feminine hygiene products, nappies, books, magazines, wallpaper), rubber (e.g. tyres, shoes, toys), stone, plaster, cement, glass or ceramic (e.g. dishes, pots/pans, food storage containers, construction and isolation material), metal (e.g. cutlery, pots, toys, jewellery) and wood (e.g. floors, furniture, toys).

This substance is used in the following products: polymers, coating products, inks and toners, fillers, putties, plasters, modelling clay, laboratory chemicals and water treatment chemicals.

This substance is used in the following areas: building & construction work, printing and recorded media reproduction, scientific research and development and municipal supply (e.g. electricity, steam, gas, water) and sewage treatment. This substance is used for the manufacture of: plastic products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, treatment of articles by dipping and pouring, roller or brushing applications, hand mixing with intimate contact only with personal protective equipment available, production of mixtures or articles by tabletting, compression, extrusion or pelletisation, transfer of substance into small containers, non-industrial spraying and laboratory work.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

This substance is used in the following products: polymers.

This substance is used in the following activities or processes at workplace: transfer of chemicals, transfer of substance into small containers, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, mixing in open batch processes, hand mixing with intimate contact only with personal protective equipment available and laboratory work.

Release to the environment of this substance can occur from industrial use: formulation of mixtures and formulation in materials.

This substance is used in the following products: polymers.

This substance is used in the following areas: mining, municipal supply (e.g. electricity, steam, gas, water) and sewage treatment, health services and building & construction work. This substance is used for the manufacture of: chemicals, plastic products, electrical, electronic and optical equipment, machinery and vehicles, mineral products (e.g. plasters, cement), metals, fabricated metal products, wood and wood products and pulp, paper and paper products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed batch processing in synthesis or formulation, closed processes with no likelihood of exposure, mixing in open batch processes, transfer of substance into small containers, batch processing in synthesis or formulation with opportunity for exposure, laboratory work and closed, continuous processes with occasional controlled exposure.

Release to the environment of this substance can occur from industrial use: for thermoplastic manufacture, as processing aid, in processing aids at industrial sites, as processing aid, of substances in closed systems with minimal release, in the production of articles and as an intermediate step in further manufacturing of another substance (use of intermediates).

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes, transfer of substance into small containers and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, in processing aids at industrial sites, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, for thermoplastic manufacture, as processing aid and of substances in closed systems with minimal release.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: keep away from heat, sparks, open flames and/or hot surfaces – No smoking; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier; avoid breathing the dust, fume, gas, mist, vapours or spray.

Response statements

In case of incident: If on skin: wash with soap and water.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • 3M Belgium BVBA/SPRL, Hermeslaan 7 1831 Diegem Belgium
  • 3M Deutschland GmbH, Carl-Schurz-Strasse 1 41453 Neuss Germany
  • 3M France SAS, 1 Parvis de l'Innovation CS 20203 95006 Cergy-Pontoise Cedex France
  • 3M United Kingdom Plc, 3M Centre, Cain Road RG12 8HT Bracknell - Berkshire United Kingdom
  • Afton Chemical S.P.R.L. (Woluwe), Alma Court Lenneke Marelaan, 8 B-1932 St-Stevens-Woluwe Belgium
  • Allnex Belgium NV/SA OR1, Anderlechtstraat 33 1620 Drogenbos Belgium
  • Alpha OR LI Inc, Merseyweg 16, PO Box 1222, 3180AE Rozenburg ZH, 3197 KG Botlek Rt Zuid Holland Netherlands
  • Alpha OR MCC Huizhou China , Merseyweg 16, PO Box 1222, 3180AE Rozenburg ZH, 3197 KG Botlek Rotterdam Zuid Holland Netherlands
  • Alpha OR MCC SAMAC, Merseyweg 16, PO Box 1222, 3180AE Rozenburg ZH, 3197 KG Botlek Rotterdam Zuid Holland Netherlands
  • ARKEMA B.V., headquarters Postbus 6030 3196 XH Vondelingenplaat Rotterdam Netherlands
  • ARKEMA PHOTOCURES, 420 rue d'Estienne d'Orves 92700 Colombes France
  • ARKEMA S.R.L. Socio Unico, Via Pregnana 63 20017 Rho Milano Italy
  • Arpadis Benelux NV, Desguinlei 88A 2018 Antwerp Belgium
  • Ashland Services BV (0311), Noordweg 9 3336 LH Zwijndrecht Netherlands
  • Avery Dennison Materials Europe BV, Willem Einthovenstraat 11 2342 BH Oegstgeest Zuid-Holland Netherlands
  • Axalta Coating Systems Germany GmbH & Co. KG, Christbusch 25 42285 Wuppertal Germany
  • B.I.G. - OR18190, Technische Schoolstraat 43a 2440 Geel Belgium
  • B.I.G. - OR634, Technische Schoolstraat 43A 2440 Geel Belgium
  • B.I.G. - OR646, Technische Schoolstraat 43A 2440 Geel Belgium
  • BASF Coatings GmbH, Glasuritstrasse 1 Postfach 6123 48136 Münster Nordrhein-Westfalen Germany
  • BASF SE, Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany
  • BorsodChem Zrt. - OR, Bolyai ter 1. H-3700 Kazincbarcika Hungary
  • Cambridge Environmental Assessments, part of RSK ADAS Europe (Ireland) Ltd, Office Suite B, Bluebell Business Centre Old Naas Rd D12XV7K Dublin Ireland
  • Celanese Europe BV, The New Atrium Strawinskylaan 3105 1077 ZX Amsterdam Netherlands
  • Chemetall GmbH, Trakehner Str. 3 60487 Frankfurt Germany
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77, D02 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • Chemical Inspection & Regulation Service Limited, Room 002, Regus Harcourt Centre D02 HW77 D02 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77, Dublin, Ireland D02 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77 D02 Dublin Ireland
  • Chemservice S.A. (H5P7), 5, an de Laengten 6776 Grevenmacher Luxembourg
  • COVANCE CRS SA 072, Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 – 5 Planta 28050 Madrid Spain
  • COVANCE CRS SA 155, Parque Empresarial Las Tablas, Edifico 1 Calle Federico Mompou, 5 - 5 Planta 28050 Madrid Spain
  • COVANCE CRS SA 156, Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 – 5 Planta 28050 Madrid Spain
  • Covestro Deutschland AG, Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany
  • CS Regulatory Ltd 2M, The Old Courthouse St Peters Churchyard DE1 1NN Derby Derbyshire United Kingdom
  • CS Regulatory Ltd 4M, The Old Courthouse St Peters Churchyard DE1 1NN Derby Derbyshire United Kingdom
  • DKSH Italia S.r.l., Via Salvatore Rosa, 14 20156 Milano Italy
  • Dow Belgium B.V.B.A., Sneeuwbeslaan 20, bus 10 2610 Wilrijik Belgium Belgium
  • DOW BENELUX B.V., Postbus 48 4530 AA Terneuzen Netherlands
  • DOW BENELUX B.V. OR-10, Postbus 48 4530 AA Terneuzen Netherlands
  • DOW BENELUX B.V. OR-11, Postbus 48 4530 AA Terneuzen Netherlands
  • DOW BENELUX B.V. OR-13, Postbus 48 4530 AA Terneuzen Netherlands
  • DOW BENELUX B.V. OR-5, Postbus 48 4530 AA Terneuzen Netherlands
  • DOW BENELUX B.V. OR-6, Postbus 48 NL-4530 AA Terneuzen Netherlands
  • DOW BENELUX B.V. OR-7, Postbus 48 NL-4530 AA Terneuzen Netherlands
  • Dow Benelux B.V. OR-20, Postbus 48 4530 AA Terneuzen Netherlands
  • Dow Benelux B.V. OR-51, Postbus 48 4530 AA Terneuzen Netherlands
  • DOW BENELUX B.V. OR-52, Postbus 48 4530 AA Terneuzen Netherlands
  • DOW BENELUX B.V. OR-53, Postbus 48 4530 AA Terneuzen Netherlands
  • Dow France SAS, 23 Avenue Jules Rimet 93200 La Plaine Saint Denis France
  • Dow Silicones Belgium SPRL, PSRC - Rue Jules Bordet Zone industrielle C 7180 Seneffe Belgium
  • Du Pont (U.K.) Limited, London Road 4th Floor, Kings Court SG1 2NG Stevenage Hertfordshire United Kingdom
  • Du Pont de Nemours (Deutschland) GmbH, Hugenottenallee 173-175 D-63263 Neu-Isenburg Hesse Germany
  • ECEM, Hogehilweg 18 1101CD Amsterdam Noord Holland Netherlands
  • Elementis UK Ltd., Caroline House 55 - 57 High Holborn WC1V 6DX London United Kingdom
  • ELGA EUROPE SRL, Via della Merlata, 8 20014 NERVIANO MILANO Italy
  • ENVIGO CRS SAU 023, Centro Industrial Santiga - Carrer Argenters, 6 08130 Santa Perpetua de Mogoda Barcelona Spain
  • ENVIGO CRS SAU 087, Centro Industrial Santiga - Carrer Argenters, 6 08130 Santa Perpetua de Mogoda Barcelona Spain
  • Envigo Research Limited 105, Shardlow Business Park London Road DE72 2GD Shardlow Derbyshire United Kingdom
  • Envigo Research Limited 170, Shardlow Business Park London Road DE72 2GD Shardlow Derbyshire United Kingdom
  • Envigo Research Limited 24, Shardlow Business Park London Road DE72 2GD Shardlow Derbyshire United Kingdom
  • Evonik Resource Efficiency GmbH, Rellinghauser Strasse 1-11 45128 Essen Germany
  • Evonik Resource Efficiency GmbH - Ro1, Kirschenallee 64293 Darmstadt Germany
  • Evonik Resource Efficiency GmbH - Ro2, Kirschenallee 64293 Darmstadt Germany
  • Evonik Resource Efficiency GmbH - Ro4, Kirschenallee 64293 Darmstadt Germany
  • Evonik Resource Efficiency GmbH – M02, Rellinghauser Straße 1-11 45128 Essen Nordrhein-Westfalen Germany
  • Evonik Röhm GmbH, Kirschenallee 64293 Darmstadt Germany
  • Evonik Röhm GmbH OR-R4, Dolivostrasse 17 64293 Darmstadt Germany
  • Experien Chemical Services (Europe) Limited, 7 Finkle Street YO7 1DA Thirsk United Kingdom
  • FujiFilm Manufacturing Europe BV, Oudenstaart 1 5047 TK Tilburg Netherlands
  • Galata Chemicals GmbH, Chemiestrasse 22 68623 Lampertheim 06 Germany
  • Gantrade Europe Limited, Birch House Fairfield Avenue TW18 4AB Staines Upon Thames Middlesex United Kingdom
  • Henkel Global Supply Chain B.V., Gustav Mahlerlaan 2970 1081 LA Amsterdam Netherlands
  • HH Compliance Ltd, Rubicon Centre C.I.T. Campus T12 Y275 Bishopstown Cork Ireland
  • INEOS Styrolution Europe GmbH, Mainzer Landstrasse 50 60325 Frankfurt am Main Germany
  • International Farg AB, Box 44 SE 424 22 Angered Sweden
  • Intertek Deutschland GmbH 1, Stangenstrasse 1 70771 Leinfelden-Echterdingen Germany
  • Intertek Deutschland GmbH 40, Stangenstrasse 1 70771 Leinfelden-Echterdingen Germany
  • Intertek Deutschland GmbH ITCI, Stangenstr. 1 70771 Leinfelden-Echterdingen Germany
  • ITW Performance Polymers, A Division of ITW Ireland, Bay 150 Shannon Industrial Estate V14 DF82 Shannon Co. Clare Ireland
  • KH Chemicals B.V., Scheepmakerij 260 3331 MB Zwijndrecht Netherlands
  • KTR Europe GmbH, Mergenthalerallee 77 65760 Eschborn Germany
  • Kuraray Europe GmbH, Philipp-Reis-Str. 4 65795 Hattersheim Germany
  • Lubrizol Advanced Materials Europe B.V.B.A, Nijverheidsstraat 30 2260 Westerlo-Oevel Belgium
  • Lubrizol Europe Coordination Center BVBA 01, Chaussee De Wavre, 1945 1945 Brussels Belgium
  • Lubrizol Europe Coordination Center BVBA 02 , Chaussee De Wavre 1945 Brussels Belgium
  • Lubrizol France SAS, 25 Quai de France 76100 ROUEN France
  • Lucite International UK Limited MI, Cassel PO Box 8 TS23 1LE Billingham United Kingdom
  • Lucite International UK Ltd, Wilton Wilton Centre TS10 4RF Redcar Cleveland United Kingdom
  • Lucite OR MCC Korea, Wilton Centre Wilton TS10 4RF Redcar Cleveland United Kingdom
  • Lucite OR MCC Thailand, Wilton Centre Wilton TS10 4RF Redcar Cleveland United Kingdom
  • Mitsubishi Polyester Film GmbH, Kasteler Str. 45 65203 Wiesbaden Germany
  • Momentive Performance Materials GmbH, Chempark Building V7 51368 Leverkusen NRW Germany
  • NAM & NAM Europe GmbH, Emil-Figge-Str. 80 44227 Dortmund(054) Germany
  • Nouryon Surface Chemistry AB, Stenunge Allé 3 - S-44485 Stenungsund - Sweden
  • Novasol S.A., Mechelsesteenweg 455 1950 Kraainem Belgium
  • NP Automotive Coating (Europe) Ltd, Britannia Park Radway Road SN3 4ND Swindon Wiltshire United Kingdom
  • OMNOVA Solutions SAS (OR of OMNOVA Solutions Inc), 14 avenue des Tropiques ZA de Courtaboeuf 2, Villejust 91955 Courtaboeuf Cedex France
  • Panasonic Industrial Devices Slovakia s.r.o., Oravicka 616 02801 Trstena Slovakia
  • Performance Specialty Products Italy Srl , Via Pontaccio 10 20121 Milano Lombardia Italy
  • PETROCHINA INTERNATIONAL (LONDON) CO., LTD, 11th Floor, The Adelphi, 1-11 John Adam Street, WC2N 6HT LONDON United Kingdom
  • PPG Industries Italia Srl Società soggetta a direzione e coordinamento da parte di PPG Industries Inc., Via Serra, 1 15028 Quattordio Italy
  • REACHLaw Ltd, Vänrikinkuja 3 JK 21 02600 Espoo Finland
  • REACHLaw Ltd., Vänrikinkuja 3 JK 21 02600 Espoo Finland
  • REACHLAw Ltd., Keilaranta 15 02150 Espoo Finland
  • Ricardo-AEA Ltd, Shoreham Technical Centre BN43 5FG Shoreham-by-Sea West Sussex United Kingdom
  • Roehm America LLC - ORR1, Dolivostrasse 17 64293 Darmstadt Germany
  • SABIC Innovative Plastics BV, Plasticslaan 1 4612 PX Bergen op Zoom Netherlands Netherlands
  • SABIC Petrochemicals B.V., Europaboulevard 1 6135 LD Sittard Netherlands
  • Sakata Inx España,S.A., C/ Mercaders 24-26. Pol.Ind.Riera de Caldes E-08184 Palau Solità i Plegamans Barcelona Spain
  • SCAS Europe S.A./N.V., Leonardo Da Vincilaan 19 B-1831 Diegem Belgium
  • Showa Denko Europe GmbH OR1, Konrad-Zuse-Platz 3 D-81829 Munich Germany
  • SOLVENTIS LTD, Bank Terrace Gomshall Lane GU59HB Guildford Surrey United Kingdom
  • Specialty Electronic Materials Netherlands B.V., Herbert H. Dowweg 5 4542NM Hoek Netherlands
  • Specialty Electronic Materials Netherlands B.V. OR-1, Herbert H. Dowweg 5 4542NM Hoek Netherlands
  • Specialty Products Poland sp. z o.o., ul. Postępu 17B 02-676 Warsaw Poland
  • SRL Dental GmbH, Giulinistr. 2 67065 Ludwigshafen Germany
  • Stadex Nederland BV as OR for Shandong, Boxbergerweg 119 7431PM Diepenveen Netherlands
  • Stahl Europe B.V., Sluisweg 10 5145PE Waalwijk Noord Brabant Netherlands
  • Stewardship Chemicals 28, Green Lowe Farm, Shawclough Road Waterfoot BB4 9SA Rossendale Lancashire United Kingdom
  • Sun Chemical B.V., Leeuwenveldseweg 3-t 1382 LV Weesp Netherlands
  • Synthomer Trading Limited, 45 Pall Mall SW1Y 5JG London United Kingdom
  • TramacoGmbH, Lise-Meitner-Allee 8 25411 Tornesch Germany
  • TSGE_7-3, Concordia House, St. James Business Park Grimbald Crag Court HG5 8QB Knaresborough North Yorkshire United Kingdom
  • TÜV SÜD Iberia S.A.U. (052), Ronda Can Fatjó 13 08290 Cerdanyola del Vallès Barcelona Spain
  • UMCO GmbH, Georg-Wilhelm-Straße 187 21107 Hamburg Germany
  • Valspar b.v., Zuiveringweg 89 8243 PE Lelystad Netherlands
  • VAMP - TECH S.p.A., Via delle Industrie 10/12 20874 Busnago Italy
  • Wacker Chemie AG, Hanns-Seidel-Platz 4 81737 Muenchen Germany
  • [Confidential], [Confidential]
  • Evonik Performance Materials GmbH, Rellinghauser Strasse 1-11 45128 Essen Germany
  • Henkel Belgium Operations N.V., Havenlaan 16 1080 Brussels Belgium
  • Henkel Italia Operations S.r.L., Via Amoretti 78 20157 Mailand Italy
  • [Confidential], [Confidential]

Substance names and other identifiers

methyl 2-methylprop-2-enoate
C&L Inventory
methyl 2-methylpropenoate
C&L Inventory
Methyl methacrylate
EC Inventory, C&L Inventory, Substance Evaluation - CoRAP, REACH pre-registration
ester metylowy kwasu metakrylowego (pl)
C&L Inventory
metacrilato de metilo (es)
C&L Inventory
metacrilato di metile (it)
C&L Inventory
metakrylan metylu (pl)
C&L Inventory
Methyl 2-methylprop-2-enoat (de)
C&L Inventory
methyl-2-methylprop-2-enoát (cs)
C&L Inventory
methyl-2-methylpropenoát (cs)
C&L Inventory
Methyl-methacrylat (de)
C&L Inventory
methyl-methakrylát (cs)
C&L Inventory
methylmethacrylaat (nl)
C&L Inventory
methylmethacrylat (da)
C&L Inventory
metil 2-metilprop-2-enoat (ro)
C&L Inventory
metil 2-metilprop-2-enoato (it)
C&L Inventory
metil 2-metilprop-2-enoát (hu)
C&L Inventory
metil 2-metilpropenoat (ro)
C&L Inventory
metil 2-metilpropenoato (pt)
C&L Inventory
metil 2-metilpropenoát (hu)
C&L Inventory
metil 2-metilpropenoāts (lv)
C&L Inventory
metil 2-metilpropenoāts-2 (lv)
C&L Inventory
metil metacrilat (ro)
C&L Inventory
metil metakrilat (sl)
C&L Inventory
metil-2-metil-2-propenoatas (lt)
C&L Inventory
metil-2-metil-prop-2-enoat (hr)
C&L Inventory
metil-2-metil-propenoat (hr)
C&L Inventory
metil-2-metilpropenoatas (lt)
C&L Inventory
metil-metacrilato (it)
C&L Inventory
metil-metakrilat (hr)
C&L Inventory
metil-metakrilát (hu)
C&L Inventory
metilmetakrilatas (lt)
C&L Inventory
metilmetakrilāts (lv)
C&L Inventory
metyl-2-metylprop-2-enoát (sk)
C&L Inventory
metyl-metakrylát (sk)
C&L Inventory
metylmetakrylat (no)
C&L Inventory
Metyyli-2-metyyliprop-2-enoaatti (fi)
C&L Inventory
Metyyli-2-metyylipropenoaatti (fi)
C&L Inventory
Metyylimetakrylaatti (fi)
C&L Inventory
metüül-2-metüülprop-2-enaat (et)
C&L Inventory
metüül-2-metüülpropenaat (et)
C&L Inventory
Metüülmetakrülaat (et)
C&L Inventory
MMA (de)
C&L Inventory
méthacrylate de méthyle (fr)
C&L Inventory
O-metyl-2-metylpropenoát (sk)
C&L Inventory
μεθακρυλικός μεθυλεστέρας (el)
C&L Inventory
мeтил-метакрилат (bg)
C&L Inventory
метил 2-метилпроп-2-еноат (bg)
C&L Inventory
метил 2-метилпропеноат (bg)
C&L Inventory
2-Propenoic acid, 2-methyl-, methyl ester
Other
2-Methyl-2- propenoic acid, methyl ester
Registration dossier
2-Methyl-2-propenoic acid methyl ester
C&L Inventory
2-Methyl-2-propenoic acid, methyl ester
C&L Inventory
2-Methyl-propenoic acid, methyl ester
C&L Inventory
2-methylprop-2-enoate
C&L Inventory
ECEM bv
Registration dossier
Metahylmethacrylate
Registration dossier
methacrylic acid methylester
C&L Inventory
methly methacrylate
C&L Inventory
Methy methacrylate
Registration dossier
Methyl 2 methylprop-2-enoate
C&L Inventory
Methyl 2-methylacrylate
Registration dossier
methyl 2-methylpropeno
C&L Inventory
methyl metacrylate
C&L Inventory
Methyl Methacrylat
C&L Inventory
Methyl Methacrylate (stabilized with 6-tert-Butyl-2,4-xylenol)
C&L Inventory
Methyl methacrylate MMA
Registration dossier
methyl methacrylate; methyl 2-methylprop-2-enoate; methyl 2-methylpropenoate
C&L Inventory
Methyl Methylpropenoate
C&L Inventory
Methyl-2-methylprop- 2-eonate
Registration dossier
METHYLMETHACRYLATE
C&L Inventory, Registration dossier
propane-1,2-diol
Registration dossier
2-(Methoxycarbonyl)-1-propene
Registration dossier
2-Propenoic acid, 2-methyl-, methyl ester (9CI)
Registration dossier
ACRYESTER M.
Registration dossier
Acrylic acid, 2-methyl-, methyl ester
Registration dossier
MAM
Registration dossier
Metacrilato de metilo (Spanish)
Registration dossier
Metakrylan metylu (Polish)
Registration dossier
methacrylate de methyle
Registration dossier
Methacrylate, methyl
Registration dossier
Methacrylic acid methyl ester (6CI, 8CI)
Registration dossier
Methacrylic acid, methyl ester
C&L Inventory, Registration dossier
Methacrylic acid, methyl ester (7CI)
Registration dossier
Methacrylsaeuremethylester
Registration dossier
Methacrylsäuremethyl ester (German)
Registration dossier
Methyl 2-methyl-2-propenoate
Registration dossier
METHYL METHACRYLATE (MMA)
Registration dossier
Methyl-alpha-methacrylate
Registration dossier
Methylester kyseliny methakrylove (Czech)
Registration dossier
Methylmethacrylaat (Dutch)
Registration dossier
Methylpropylene-2-carboxylate
Registration dossier
Metil metacrilato (Italian)
Registration dossier
Méthacrylate de méthyl (French)
Registration dossier
Pegalan
Registration dossier
Prop-2-enoate, 2-methyl-, methyl
C&L Inventory, Registration dossier
This substance is a monomer in an imported polymer, therefore no trade names are available and/or relevant.
Registration dossier
VISIOMER®MMA
Registration dossier
1196968-39-4
Deleted CAS number
Other
1227277-87-3
Deleted CAS number
Other
1451188-71-8
Deleted CAS number
Other
1453489-95-6
Deleted CAS number
Other
162221-54-7
Deleted CAS number
Other
211862-43-0
Deleted CAS number
Other
220713-32-6
Deleted CAS number
Other
607-035-00-6
Index number
C&L Inventory
80-62-6
CAS number
EC Inventory, C&L Inventory, Substance Evaluation - CoRAP, Registration dossier, REACH pre-registration, Other
874217-13-7
Deleted CAS number
Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 2 studies submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [1]
C Odour
Pungent (100%) [1]
C Substance type
Other (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Melting/freezing point

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 4
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Boiling point

Study results
  • 6 studies submitted
  • 1 study processed
R Boiling point
100.36 °C @ 101.325 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 5
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Boiling point at 101 325 Pa
100.36 °C

Density

Study results
  • 10 studies submitted
  • 1 study processed
R Relative density
0.94 @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 3 6
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
0.94

Vapour pressure

Study results
  • 7 studies submitted
  • 1 study processed
R Vapour pressure
30 - 100 hPa @ 16.67 - 39.4 °C [3]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 3 2
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
37 hPa @ 20 °C

Partition coefficient

Study results
  • 10 studies submitted
  • 1 study processed
R Log Pow
1.38 @ 20 °C and pH 7 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 2 6
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
1.38 @ 20 °C

Water solubility

Study results
  • 3 studies submitted
  • 1 study processed
R Water solubility (mass/vol.)
15.3 g/L @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
15.3 g/L @ 20 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other 1 2
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 9 studies submitted
  • 1 study processed
R Flash point
10 °C @ 101.325 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 5 1 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Flash point at 101 325 Pa
10 °C

Auto flammability

Study results
  • 6 studies submitted
  • 2 studies processed
R Autoflammability / self-ignition
430 - 435 °C @ 101.3 - 101.325 kPa [2]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence 1
Other 1 2
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Autoflammability / self-ignition at 101 325 Pa
435 °C

Flammability

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Highly flammable (100%)

Explosiveness

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 2 studies submitted
  • 1 study processed
R dynamic viscosity (in mPa s)
0.53 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Dynamic viscosity at 20 °C
0.53 mPa.s

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 7 studies submitted
  • 1 study processed
R Dissipation half life (DT50)
6.997 - 24.179 h [2]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 3 2
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Hydrolysis

Study results
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1 4
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in water - screening tests

Study results
  • 16 studies submitted
  • 1 study processed
C Interpretation of results
Readily biodegradable (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 5 1 9
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Adsorption/desorption

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Henrys law constant (H)

Study results
  • 3 studies submitted
  • 1 study processed
R H - (pressure) m³/mol
14.7 Pa m³/mol @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Distribution modelling

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence
Other 1
Data waiving
no waivers

No summary exists for this scientific endpoint

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 940 µg/L (1)
Intermittent releases (freshwater) 940 µg/L (1)
Marine water 940 µg/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 10 mg/L (1)
Sediment (freshwater) 5.74 mg/kg sediment dw (1)
Sediment (marine water) No exposure of sediment expected (1)
Hazard for Air
Air -
Hazard for Terrestrial Organism
Soil 1.47 mg/kg soil dw (1)
Hazard for Predators
Secondary poisoning -

Short–term toxicity to fish

Study results
  • 8 studies submitted
  • 1 study processed
P/RResults
LC50 (4 days) 79 mg/L [1]
NOEC (4 days) 40 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other 5
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Short–term toxicity to aquatic invertebrates

Study results
  • 4 studies submitted
  • 1 study processed
P/RResults
EC50 (48 h) 69 mg/L [1]
NOEC (48 h) 48 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 2
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
NOEC (21 days) 37 mg/L [1]
LOEC (21 days) 68 mg/L [1]
EC50 (21 days) 49 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 5 studies submitted
  • 1 study processed
P/RResults
EC50 (72 h) 110 mg/L [2]
NOEC (72 h) 49 - 110 mg/L [2]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 2 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 8 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 7
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Sediment toxicity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 208 mg/m³ repeated dose toxicity
Acute /short term: - -
Local Effects
Long-term: (DNEL) 208 mg/m³ repeated dose toxicity
Acute /short term: - -
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 13.67 mg/kg bw/day repeated dose toxicity
Acute /short term: - -
Local Effects
Long-term: (DNEL) 1.5 mg/cm² sensitisation (skin)
Acute /short term: (DNEL) 1.5 mg/cm² sensitisation (skin)
EYE Exposure
-
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 74.3 mg/m³ repeated dose toxicity
Acute /short term: - -
Local Effects
Long-term: (DNEL) 104 mg/m³ repeated dose toxicity
Acute /short term: - -
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 8.2 mg/kg bw/day repeated dose toxicity
Acute /short term: - -
Local Effects
Long-term: (DNEL) 1.5 mg/cm² sensitisation (skin)
Acute /short term: (DNEL) 1.5 mg/cm² sensitisation (skin)
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: - -
Acute /short term: - -
EYE Exposure
-

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 47 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 2 1 1
Supporting study 8
Weight of evidence
Other 27 8
Data waiving
no waivers
Study data: dermal absorption
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Acute toxicity

Study results
oral
  • 16 studies submitted
  • 2 studies processed
P/RResults
LD50 7 900 - 9 400 mg/kg bw (rat) [2]

Type of Study provided
oral
Studies with data
Key study
Supporting study
Weight of evidence 2
Other 10 4
Data waiving
no waivers
inhalation
  • 41 studies submitted
  • 1 study processed
P/RResults
LC50 (4 h) 29.8 mg/L air (rat) [1]

inhalation
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 38 1
Data waiving
no waivers
dermal
  • 5 studies submitted
  • 1 study processed
P/RResults
LD50 5 000 mg/kg bw (rabbit) [1]

dermal
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 4
Data waiving
no waivers
other routes
  • 11 studies submitted
  • 0 studies processed

No automatically processable data submitted

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other 4 7
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Irritation / corrosion

Study results
Study data: skin
  • 11 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study
Supporting study
Weight of evidence 2
Other 9
Data waiving
no waivers
Study data: eye
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study
Supporting study
Weight of evidence 2
Other 4
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
Adverse effect observed (irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 48 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 41 6
Data waiving
no waivers
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
Adverse effect observed (sensitising)
Respiratory sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 5 studies submitted
  • 1 study processed
P/RResults
NOAEL (rat): 124.1 - 164 mg/kg bw/day [2]

Type of Study provided
Study data: oral
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 3 1
Data waiving
no waivers
Study data: inhalation
  • 42 studies submitted
  • 3 studies processed
P/RResults
NOAEC (rat): 104 - 1 640 mg/m³ air [2]
NOAEC (rat): 500 - 1 000 ppm [4]
LOAEC (rat): 416 mg/m³ air [1]
LOAEC (rat): 250 ppm [2]

Study data: inhalation
Studies with data
Key study 3
Supporting study 2
Weight of evidence
Other 28 9
Data waiving
no waivers
Study data: dermal
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Genetic toxicity

Study results
Study data: in vitro
  • 28 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 2
Supporting study 2
Weight of evidence 3
Other 14 7
Data waiving
no waivers
Study data: in vivo
  • 11 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 1
Supporting study 1
Weight of evidence 1
Other 3 5
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Carcinogenicity

Study results
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other 2 2
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study
Supporting study
Weight of evidence
Other 1 3
Data waiving
no waivers
Study data: developmental
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other 7
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Neurotoxicity

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 3
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Immunotoxicity

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant