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Toxicological information

Sensitisation data (human)

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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
other: case reports
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Detailed information on the exposure history of the patients studied, including the purity of the (meth)acrylate compounds is missing. Bias-positive: patients of dermatologists or dermal clinics are a cohort preselected for having a problem with the skin.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Ten years of patch testing with the (meth)acrylate series.
Author:
Kanerva Lasse, Jolanki R., Estlander T.
Year:
1997
Bibliographic source:
Contact Dermatitis 37(6): 255 - 258
Reference Type:
review article or handbook
Title:
Occupational skin disease from acrylics in dental personnel.
Author:
Kanerva L
Year:
1999
Bibliographic source:
cited in Dyall-Smith D, Marks R (1997) Dermatology at the Millennium. Parthenon Publishing Group, London: 514-519

Materials and methods

Type of sensitisation studied:
skin
Study type:
case report
Principles of method if other than guideline:
case reports, patch test
During 1985 - 1995, a total of 275 patients with a history of exposure to (meth)acrylates were patch tested with the (meth)acrylate series of 
Chemotechnique Diagnostics (Malmö, Sweden) containing about 30 (meth)acrylates.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed

Method

Type of population:
other: patients with dermatitis with previous contact with (meth)acrylate (no further details)
Subjects:
- Number of subjects exposed: 271 (tested to methyl methacrylate)
- Other: patients with suspected contact allergy were patch tested
Route of administration:
dermal

Results and discussion

Results of examinations:
48 patients (17.5 %) had an allergic reaction to at least 1 (meth)acrylate. The (meth)acrylates most often provoking an allergic patch test reaction were 2-Hydroxyethyl acrylate (2-HEA, 16 of 132 patiens; 12.1 %), 2-Hydroxypropyl methacrylate (2-HPMA, 29 of 242 patients; 12.0 %), 2-Hydroxyethyl 
methacrylate (2-HEMA, 31 of 273 patients;  11.4 %) and Methylmethacrylate (MMA, 20 of 271 patients;  7.4 %).

Applicant's summary and conclusion

Conclusions:
For Methyl methacrylate, 271 individuals were tested at a patch test concentration of 2% (w/w). Of these, 20 (7.4%) showed a positive reaction.
Executive summary:

During 1985 - 1995, a total of 275 patients with a history of exposure to (meth)acrylates were patch tested with the (meth)acrylate series of Chemotechnique Diagnostics (Malmö, Sweden) containing about 30 (meth)acrylates.

48 patients (17.5 %) had an allergic reaction to at least 1 (meth)acrylate. The (meth)acrylates most often provoking an allergic patch test reaction were 2-Hydroxyethyl acrylate (2-HEA, 16 of 132 patiens; 12.1 %), 2-Hydroxypropyl methacrylate (2-HPMA, 29 of 242 patients; 12.0 %), 2-Hydroxyethyl methacrylate (2-HEMA, 31 of 273 patients;  11.4 %) and Methylmethacrylate (MMA, 20 of 271 patients;  7.4 %).