α,α-bis[4-(dimethylamino)phenyl]-4-(phenylamino)naphthalene-1-methanol

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Experimental tests performed using standard test guuidelines

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

GLP compliance:

no

Type of method:

other: spectrophotometric method

Key result

Water solubility:

0.006 mg/L

Temp.:

25 °C

Remarks on result:

other: No other details available

PRELIMINARY TEST AT 96 h

Concentration obtained (mg/L)		Average	Absorbance	Average	Total Dilution factor(if any)	Water Solubility Value by Standard Curve (mg/L)	Average
R1	0.368	0.369	0.052	0.053	-	0.368	0.369
R2	0.369		0.053		-	0.369

 

CONFIRMATORY TEST AT 24, 48 AND 72 h

Sample stirring (h)	Concentration obtained		Average	Absorbance	Average	Dilution factor	Water Solubility value obtained (mg/L)	Average
24 h	R1	0.0064	0.0058	0.0009	0.0008	-	0.0064	0.0058
	R2	0.0052		0.0007			0.0052
48 h	R1	0.0063	0.0064	0.0009	0.0009	-	0.0063	0.0064
	R2	0.0065		0.0009			0.0065
72 h	R1	0.0069	0.0065	0.001	0.001	-	0.0069	0.0065
	R2	0.0061		0.0009			0.0061

 

CALCULATION

The water solubility for 24 h, 48 h and 72 h was calculated as follows: Mean water solubility value for 24 h + 48 h + 72 h run sample.

= (0.0058 + 0.0064 + 0.0065)/3

= 0.006 mg/L

pH

pH
Preliminary Test		Confirmatory Test
96 h			24 h	48 h	72 h
R1	6.48	R1	6.52	6.53	6.52
R2	6.42	R2	6.49	6.51	6.54

 

Conclusions:

The solubility of the test chemical in water was determined to be 0.006 mg/l at 25 °C which indicates that the test chemical was insoluble in water.

Executive summary:

The study was conducted to determine the solubility of test chemical in ultra-pure water, according to the OECD guideline 105 (Adopted by the Council on 27th July 1995) and OECD 101(Adopted: 12 May 1981). Test was conducted at 25±2 °C in two stages; preliminary test for 96 h, followed by confirmatory test for 24 h, 48 h and 72 h in replicates. The final water solubility value was calculated based on average of the individual values obtained after 24 h, 48 h and 72 h. The difference between the average values in three vessels was not observed more than 15%. The water solubility value was observed to be 0.006 mg/L at 25±2 °C.

Description of key information

The water solubility determination of test chemical was done as per the OECD 105 The solubility of the test chemical in water was determined to be 0.006 mg/l at 25° which indicates that the test chemical was insoluble in water.

Key value for chemical safety assessment

Water solubility:

0.006 mg/L

at the temperature of:

25 °C

Additional information

The study was conducted to determine the solubility of test chemical in ultra-pure water, according to the OECD guideline 105 (Adopted by the Council on 27th July 1995) and OECD 101(Adopted: 12 May 1981). Test was conducted at 25±2 °C in two stages; preliminary test for 96 h, followed by confirmatory test for 24 h, 48 h and 72 h in replicates. The final water solubility value was calculated based on average of the individual values obtained after 24 h, 48 h and 72 h. The difference between the average values in three vessels was not observed more than 15%. The water solubility value was observed to be 0.006 mg/L at 25±2 °C.