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Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

Endpoint:
sub-chronic toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Results issued from reviewed document but only brief summary was available.

Data source

Reference
Reference Type:
secondary source
Title:
OECD SIDS 1,1,2-trichloroethane
Author:
UNEP
Year:
2000
Bibliographic source:
UNEP Publications, Tokyo

Materials and methods

Principles of method if other than guideline:
Not reported
GLP compliance:
not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Name of the test substance (as cited in the test report) : 1,1,2-trichloroethane.

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female
Details on test animals and environmental conditions:
No data

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
other: no data
Remarks on MMAD:
MMAD / GSD: no data
Details on inhalation exposure:
no data
Analytical verification of doses or concentrations:
not specified
Details on analytical verification of doses or concentrations:
no data
Duration of treatment / exposure:
6 months (chronic study)
Frequency of treatment:
7 h/d, 5 d/wk
Doses / concentrations
Remarks:
Doses / Concentrations:
15 ppm or 83 mg/m3 (calculated daily dose; 11.1 mg/kg bw/day)
Basis:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
no data
Positive control:
no data

Examinations

Observations and examinations performed and frequency:
no data
Sacrifice and pathology:
no data
Other examinations:
no data
Statistics:
no data

Results and discussion

Results of examinations

Clinical signs:
no effects observed
Mortality:
no mortality observed
Body weight and weight changes:
no effects observed
Food consumption and compound intake (if feeding study):
not specified
Food efficiency:
not specified
Water consumption and compound intake (if drinking water study):
not specified
Ophthalmological findings:
not specified
Haematological findings:
no effects observed
Clinical biochemistry findings:
no effects observed
Urinalysis findings:
not specified
Behaviour (functional findings):
not specified
Organ weight findings including organ / body weight ratios:
no effects observed
Gross pathological findings:
no effects observed
Histopathological findings: non-neoplastic:
no effects observed
Histopathological findings: neoplastic:
not specified
Details on results:
No substance-related histopathological, hematological and biochemical changes were observed. Body weight gain, organ weights and mortality
remained unaffected.

Effect levels

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Dose descriptor:
NOAEL
Effect level:
11.1 mg/kg bw/day (actual dose received)
Sex:
male/female
Basis for effect level:
other: No substance-related histopathological, hematological and biochemical changes were observed. Body weight gain, organ weights and mortality remained unaffected.
Dose descriptor:
NOAEC
Effect level:
83 mg/m³ air (nominal)
Sex:
male/female
Basis for effect level:
other: No substance-related histopathological, hematological and biochemical changes were observed. Body weight gain, organ weights and mortality remained unaffected.

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
Repeated inhalation exposure (7 hours/day, 5 days/week) of rat to 83 mg of 1,1,2-trichloroethane/m3 air for 6 months did not lead to any substance-related effects. Therefore, NOAEC was considered to be 83 mg/m3, equivalent to a NOAEL of roughly 11.1 mg/kg bw/day in rat.
Executive summary:

Repeated inhalation exposure (7 hours/day, 5 days/week) to 83 mg of 1,1,2-trichloroethane/m3 air for 6 months did not lead to substance-related histopathological, hematological and biochemical changes in rat. Body weight gain, organ weights and mortality remained unaffected. Therefore, NOAEC was considered to be 83 mg/m3, equivalent to a NOAEL of roughly 11.1 mg/kg bw/day in rat.