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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1969
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: The method, test conditions and design were not sufficiently detailed.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Range-finding|toxicity data: list VII
Author:
Smyth, H.F., Carpenter, C.P., Weil, C.S., Pozzani, U.C.,|Striegel, J.A., Nycum, J.S.
Year:
1969
Bibliographic source:
American Ind. Hgy. Assoc. J., 30|(5):470-476.
Reference Type:
publication
Title:
Range-finding|toxicity data: list VII
Author:
Smyth, H.F., Carpenter, C.P., Weil, C.S., Pozzani, U.C.,|Striegel
Year:
1962
Bibliographic source:
American Ind. Hgy. Assoc. J., 23: 95-107

Materials and methods

Principles of method if other than guideline:
Method: Draize test briefly described in the publication of Smyth (1962). Observation following 24-h application of 0.01 mL of test substance on rabbit skin.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Name of the test substance (as cited in the test report) : 1,1,2-trichloroethane.

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals and environmental conditions:
no data

Test system

Type of coverage:
open
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
0.01 mL
Duration of treatment / exposure:
1 day
Observation period:
14 day
Number of animals:
no data
Details on study design:
no data

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Time point:
other: 24 h
Score:
2
Max. score:
10
Reversibility:
fully reversible
Irritant / corrosive response data:
Slight capillary congestion was observed after single non occlusive application of 0.01 ml 1,1,2-trichloroethane (14.4 mg).
Other effects:
no data

Any other information on results incl. tables

no data

Applicant's summary and conclusion

Conclusions:
Under test conditions, the test item was found to be slightly irritating (irritation score: 2/10).
Executive summary:

Skin irritation testing was performed using Draize test briefly described in the publication of Smyth (1962). Observation was performed following 24-h application of 0.01 mL of test substance on rabbit skin. Application site was not covered following application.

Under test conditions, the test item was found to be slightly irritating (irritation score: 2/10).