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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1976
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Test conditions, design and results not sufficiently described.

Data source

Reference
Reference Type:
publication
Title:
Irritating power of the principal aliphatic chloride solvents on the skin and ocular mucosa of the rabbit
Author:
Duprat, P., Delsaut, L., Gradiski, D.
Year:
1976
Bibliographic source:
Eur. J. Toxicol. Environ., 9, 171-177

Materials and methods

Principles of method if other than guideline:
Draize method
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Name of the test substance (as cited in the test report) : 1,1,2-trichloroethane.
- Analytical purity: > 98%
- Density: 1.443
- Origin: FLUCKA

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White
Details on test animals or tissues and environmental conditions:
application of 1,1,2-trichloroethane at 162 mg (0.1 ml) into the conjunctival sac of the rabbit eye

Test system

Vehicle:
unchanged (no vehicle)
Controls:
yes, concurrent no treatment
Amount / concentration applied:
162 mg (0.1 ml)
Observation period (in vivo):
24h, 7 and 14 days
Number of animals or in vitro replicates:
6

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
animal #6
Time point:
other: 2 weeks
Score:
8
Max. score:
110
Reversibility:
fully reversible within: after 2 weeks
Other effects:
After application of 1,1,2-trichloroethane at 162 mg (0.1 ml) into the conjunctival sac of the rabbit eye, a weak catarrhalic conjunctivitis as well as epithelial abrasion were observed. In addition, a healing keratitis was observed after 7 days. These symptoms completely disappeared within 2 weeks.

Applicant's summary and conclusion

Interpretation of results:
slightly irritating
Remarks:
Migrated information Criteria used for interpretation of results: other: Kay and Calandra (1962)
Conclusions:
Under test conditions, 1,1,2-trichloroethane is considered to be slightly irritating to eyes.
Executive summary:

After application of 1,1,2-trichloroethane at 162 mg (0.1 ml) into the conjunctival sac of the rabbit eye, a weak catarrhalic conjunctivitis as well as epithelial abrasion were observed. In addition, a healing keratitis was observed after 7 days. These symptoms completely disappeared within 2 weeks.

Under test conditions, 1,1,2-trichloroethane is considered to be slightly irritating to eyes.