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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1969
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Test conditions and design were not sufficiently detailed.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Range-finding toxicity data: list VII
Author:
Smyth, H.F., Carpenter, C.P., Weil, C.S., Pozzani, U.C., Striegel, J.A., Nycum, J.S.
Year:
1969
Bibliographic source:
J. American Ind. Hgy. Assoc, 30, 470-476
Reference Type:
publication
Title:
Range-finding toxicity data: list VI
Author:
Smyth, H.F., Carpenter, C.P., Weil, C.S., Pozzani, U.C., Striegel, J.A., Nycum, J.S.
Year:
1962
Bibliographic source:
J. American Ind. Hgy. Assoc, 23, 95-107

Materials and methods

Principles of method if other than guideline:
The method used was briefly described in the publication of Smyth et al. (1962). 5 male rats/dose were orally gavaged using a logarythmic series of doses.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Test substance: no data
Name of the test substance (as cited in the test report) : 1,1,2-trichloroethane.

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals and environmental conditions:
Carworth-Wistar male rats were used. They were 4 to 5 weeks of age and 90 to 120 grams in weight, have been reared in the testing laboratory and maintained from time of weaning on Rockland rat diet, complete.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
no data
Doses:
Logarythmic series of doses differing by a factor of two
No. of animals per sex per dose:
5 males
Control animals:
not specified
Details on study design:
no data
Statistics:
Based upon mortalities during a 14-day observation period, the most probable LD50 value and its fiducial range are estimated by the Method of Thompson (1947) using the tables of Weil (1952).

Results and discussion

Preliminary study:
no data
Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
837 mg/kg bw
95% CL:
678 - 1 025
Sex:
male
Dose descriptor:
LD50
Effect level:
0.58 mL/kg bw
95% CL:
0.47 - 0.71
Mortality:
non data
Clinical signs:
no data
Body weight:
no data
Gross pathology:
no data
Other findings:
no data

Any other information on results incl. tables

The LD50 value was reported to be 0.58 mL/kg (corresponding to 837 mg/kg bw).

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The acute toxicity (LD50) of 1,1,2-trichloroethane is reported to be 837 mg/kg by oral administration in rats.
Executive summary:

In this test, 5 male rats/dose were orally gavaged using a logarythmic series of doses.

The LD50 of 1,1,2-trichloroethane was estimated to be 837 mg/kg by oral administration in rats.