Registration Dossier

Administrative data

Description of key information

Both results for dermal and eye irritation were issued from the same 2 studies which were suffering severe limitations because being poorly described. Therefore, no key parameters were defined.

Key value for chemical safety assessment

Additional information

The substance was reported to be either slightly or highly irritating when rabbits were exposed dermally for 24 hours, depending whether the substance was applied using an open method (Smyth et al., 1969) or occlusive patches (Duprat et al., 1976).

The substance was reported to be slightly irritating to the eyes in both studies (Smyth et al., 1969; Duprat et al., 1976).


Effect level: empty Endpoint conclusion: Adverse effect observed

Effect level: empty Endpoint conclusion: Adverse effect observed

Effect level: empty Endpoint conclusion: Adverse effect observed

Justification for classification or non-classification

Following revision of the classification by EC authorities, R66 (R66 Repeated exposure may cause skin dryness or cracking) was deemed to be more appropriate than R38, as no standard guideline test (4-hour exposure) was available and the substance is clearly defatting as it was shown in some human exposure studies.