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EC number: 203-733-6
CAS number: 110-05-4
Viability / Mortality: No intercurrent
deaths occurred during the course of the study.
Clinical Signs: No clinical signs were
recorded throughout the entire observation period.
Body Weights: The body weight of the animals
was within the range commonly recorded for this strain and age.
The primary eye irritation potential of
di-tert-butyl peroxide (CAS# 110-05-4) was investigated according to
OECD test guideline no. 405. The test item was applied by instillation
of 0.1 mL into the left eye of each of three young adult New Zealand
White rabbits. Scoring of irritation effects was performed approximately
1, 24, 48 and 72 hours after test item instillation.
The mean score was calculated across 3
scoring times (24, 48 and 72 hours after instillation) for each animal
for corneal opacity, iris light reflex and redness and chemosis of the
conjunctivae. The individual mean scores for corneal opacity and iris
light reflex were 0.00 for all three animals. The individual mean scores
for the conjunctivae were 1.00, 0.33 and 0.33 for reddening and 0.00,
0.00 and 0.00 for chemosis, respectively.
The instillation of di-tert-butyl peroxide
(CAS# 110-05-4) into the eye resulted in mild, early onset and transient
ocular changes, such as reddening and swelling of the conjunctivae and
reddening of the sclerae. These effects were reversible and were no
longer evident 72 hours after treatment, the end of the observation
period for all animals. No abnormal findings were observed in the cornea
or for the iris light reflex of any animal at any of the examinations.
No corrosion was observed at any of the measuring intervals. No staining
of the treated eyes by the test item was observed and no clinical signs
Thus, the test item did not induce
significant or irreversible damage to the rabbit eye.
Based upon the referred classification
criteria (Regulation (EC) No 1272/2008), di-tert-butyl peroxide (CAS#
110-05-4) is not classified with respect to eye irritation in rabbits.
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