Registration Dossier

Administrative data

Link to relevant study record(s)

Description of key information

No substance specific data on metabolism and kinetics are available.
Based on physical-chemical characteristics, particularly water solubility (ca. 170 mg/l), octanol-water partition coefficient (experimental log Kow 3.2,) and vapour pressure (approximately 31 hPa at 25°C), some level of absorption by oral, dermal and inhalation routes is expected. This is supported by results of the OECD 422 study in rats in which systemic effects (increased liver and kidney weights) were found after oral dosing for at least 28 days. It is further supported by interim results of an OECD 413 study in which increased liver and kidney weights were found after inhalation exposure for 90 days. The substance is not a skin irritant; therefore no increase of skin absorption is expected.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential
Absorption rate - oral (%):
100
Absorption rate - dermal (%):
50
Absorption rate - inhalation (%):
100

Additional information

No substance specific data on metabolism and kinetics are available.

Based on physical-chemical characteristics, particularly water solubility (ca. 170 mg/l), octanol-water partition coefficient (experimental log Kow 3.2,) and vapour pressure (approximately 31 hPa at 25°C), some level of absorption by oral, dermal and inhalation routes is expected. This is supported by results of the OECD 422 study in rats in which systemic effects (increased liver and kidney weights) were found after oral dosing for at least 28 days. It is further supported by interim results of an OECD 413 study in which increased liver and kidney weights were found after inhalation exposure for 90 days. The substance is not a skin irritant; therefore no increase of skin absorption is expected.