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EC number: 203-733-6
CAS number: 110-05-4
Five male and five female RccHan:WIST
(SPF) rats were treated withdi-tert-butyl peroxide (CAS# 110-05-4)at
2000 mg/kg by dermal application. The test item was applied undiluted as
delivered from the Sponsor at a volume dosage of 2 mL/kg. The
application period was 24 hours.
The animals were examined daily during
the acclimatization period and mortality, viability and clinical signs
were recorded. All animals were examined for clinical signs withinthe
first 30 minutesand at approximately 1, 2, 3 and 5 hours after treatment
on day 1 and once daily during test days 2 - 15. Local signs were noted
once daily from test day 2 - 15. Mortality/viability was recorded
withinthe first 30 minutesand at approximately 1, 2, 3 and 5 hours after
administration on test day 1 (with the clinical signs) and twice daily
2 - 15. Body weights were recorded on day 1 (prior to administration)
and on days 8 and 15. All animals were necropsied and examined
No deaths occurred during the study.
No clinical signs were evident during
the course of the study.
The body weight of the animals was
within the range commonly recorded for this strain and age.
Local effects included slight
generalized erythema initally in two males after removal of the
semi-occlusive bandage 24 hours after administration. This finding
persisted in one of the two males on the following day. Erythema was not
seen in any animal from day 4 onwards. Slight desquamation was noted in
one male on the last two observation days. No dermal changes were seen
in the remaining two males or in the females.
Dermal sores were noted on the treated
skin of one male (no. 1) and were considered to be related to the
treatement with the test item.
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