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EC number: 203-733-6
CAS number: 110-05-4
Temperature, relative humidity and
oxygen concentration during exposure were considered to be satisfactory
for this type of study.
Data on temperature, relative
humidity and oxygen concentration are presented in the following table:
Hours after exposure start
The nominal aerosol concentration was 22
mg/L air.The chemical aerosol concentration determined was 23 mg/L
air as targeted.The aerosol concentration was stable during the
exposure period.The nominal vapor concentration was slightly lower
than the concentration determined chemically. This small difference was
considered to be within the variation of the assay for chemical analysis
and accordingly it was concluded that the efficiency was close to 100%.
Data on chemical concentration are
presented in the following table:
Amount of Test Item in Washbottles
Chemical Vapor Concentration
07:30 – 07:35
08:30 – 08:35
09:30 – 09:35
10:30 – 10:35
A group of three male and three female
albino rats [RccHan:WIST(SPF)] was exposed by nose-only, flow-past
inhalation for four hours to the test item at a chemically determined
concentration of 23 mg/L air.All animals were observed for clinical
signs and mortality during the inhalation exposure and theobservation
period of 14 days. Body weights were recorded prior to exposure on test
day 1, and during the observation period on test days 2, 4, 8 and 15
before necropsy. On day 15 all animals were sacrificed and necropsied.
The ranges of aerosol concentration,
temperature, relative humidity, oxygen content and airflow rate measured
during the exposure were considered to be satisfactory for a study of
this type. In addition, the test item was considered to be respirable to
All animals survived the scheduled
Tachypnea and shivering were recorded
during exposure until 1 hour after exposure end. Ruffled fur was
observed after exposure on test day 1 and test day 2. There were no
clinical signs from test day 3 onwards.
There were slight effects on body
weight from test day 1 to 4.
No macroscopic findings were recorded
In conclusion, the LC50 of
di-tert-butyl peroxideobtained in this study was estimated to be greater
than 22 mg/L air (nominally determined mean aerosol concentration).
There was no indication of relevant sex-related differences in toxicity
of the test item.
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