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EC number: 203-733-6
CAS number: 110-05-4
Two groups, each consisting of three female RccHan:WIST (SPF) rats, were
treated with di-tertbutyl peroxide (CAS# 110-05-4) by oral gavage
administration at a dosage of 2000 mg/kg body weight. The test item was
formulated in corn oil at a concentration of 0.2 g/mL and administered
at a dosing volume of 10 mL/kg. The animals were examined daily during
the acclimatization period and mortality, viability and clinical signs
were recorded. All animals were examined for clinical signs within the
first 30 minutes and approximately 1, 2, 3 and 5 hours after treatment
on day 1 and once daily during test days 2-15. Mortality/viability was
recorded within the first 30 minutes and approximately 1, 2, 3 and 5
hours after administration on test day 1 (with the clinical signs) and
twice daily during days 2 - 15. Body weights were recorded on day 1
(prior to administration) and on days 8 and 15. All animals were
necropsied and examined macroscopically. All animals survived until the
end of the study period. In one female, slight shivering was noted 3
hours post treatment. Otherwise, no clinical signs were observed until
the end of the observation period. The body weight of the animals was
within the range commonly recorded for this strain and age. No
macroscopic findings were recorded at necropsy. The median lethal dose
of di-tert-butyl peroxide (CAS# 110-05-4) after single oral
administration to female rats, observed over a period of 14 days is:
LD50 (female rat): greater than 2000 mg/kg body weight
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