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EC number: 203-733-6
CAS number: 110-05-4
A multistage model of carcinogenesis using
mouse skin was used to evaluate the carcinogenic potential of DTBP. DTBP
was tested for its ability to increase biomarkers of tumor promotion in
mouse skin, i.e. sustained epidermal hyperplasia, dermal inflammation
and oxidative DNA damage using SENCAR mice exposed topically for 4
weeks. DTBP did not exhibit significant increases in all three
biomarkers associated with tumor promoting activity.
The study was conducted to evaluate the skin
tumor-promoting potential of some organic peroxides including
di-tert-butyl peroxide in the two-stage initiation promotion study.
Female SENCAR mice were initiated dermally with DMBA followed by
di-tert-butyl peroxide. The number and incidence of skin tumors were
determined after 60 weeks.
Di-tert-butyl peroxide, was totally inactive
in promoting papillomas or carcinomas in initiated skin. [Gimenez-Conti
et al TOXICOLOGY AND APPLIED PHARMACOLOGY 149, 73–79 (1998)]
The study was conducted to determine the
short -term effects of BzPo and compared them with the short-term
effects of seven other organic peroxides. In the present paper, the
authors evaluated short-term markers of tumor promotion ( hyperplasia,
induction of dark basal keratinocytes and induction of ornithine
decarboxylase activity) in order to correlate these parameters with the
characteristics of the different compounds and to establish conditions
for future tumor promotion experiments.
The authors concluded that, "The data
presented here further support the association between free radicals and
tumor promotion since all of the compounds, with the exception of one,
DTBP, were active in inducing the short-term markers of tumor
promotion." (Gimenez-Conti et al Carcinogenesis vol. 2 no.4 pp.563-569,
A number of investigations have been conducted over the years to determine the initiation/promotion activity of di-tert-butyl peroxide (DTBP). Taken together, DTBP was inactive as an initiator or promotor.
DTBP did not induce short term markers of
tumor promotion in two studies with mice. DTBP was inactive in promoting
papillomas or carcinomas in initiated skin. No skin tumors developed
following dermal application of DTBP for 81 weeks or for 80 weeks when
applied prior to a promotor.
DTBP does not appear to have initiating or
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