Registration Dossier

Administrative data

Description of key information

According to OECD TG 407  male and female Sprague-Dawley rats  received 0, 4, 20, 100 mg/kg bw/d dissolved in sesame oil by gavage for 28 days. The NOAEL was 4 mg/kg bw/d based on changes in red blood cell parameters, on hemolytic anemia with microscopic changes in the spleen and increase in relative  liver weights in  the next higher dose and increase in relative spleen weight at 100 mg/kg bw/d (Hoechst AG 1993).

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Dose descriptor:
NOAEL
4 mg/kg bw/day

Mode of Action Analysis / Human Relevance Framework

Additional information

1,2-Dichloro-4-nitrobenzene shall be registrated according to Regulation (EC) 1907/2008 (REACH) Article 18 (transported isolated intermediate) and no studies are required according to REACH Annex VII.

Justification for classification or non-classification

1,2-Dichloro-4-nitrobenzene shall be registrated according to Regulation (EC) 1907/2008 (REACH) Article 18 (transported isolated intermediate) and no studies are required according to REACH Annex VII.