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EC number: 202-764-2
CAS number: 99-54-7
1,2 -dichloro-4 -nitrobenzene, tested in the Ames test according to OECD
TG 471 with and without a metabolic activation system and up to
cytotoxicity, yielded a positive result (JETOC 2005) 1,2 -dichloro-4
-nitrobenzene technical grade was tested in the CHO/HPRT Mammalian cell
forward gene mutation assay and yielded negative result (Monsonto Co
1986). Thus ist could be shown that the positive result in an bacterial
mutation test could not be confirmed in an gene mutation test using a
mammalian cell system.
1,2-dichloro-4-nitrobenzene shall be registrated according to the
Regulation (EC) 1907/2008 (REACH) Article 18 (transported isolated
intermediate) and according to ANNEXVII no studies on chromosome
aberration are required or need to be considered.
Based on the above discussed experimental results, there is no reason
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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