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EC number: 202-764-2
CAS number: 99-54-7
The adverse effects 1,2 -dichloro-4 -nitrobenzene towards the growth of aquatic algae are characterized by EC50(48 h) of 2.50 mg/L as well as a NOEC of 0.15 mg/L referring to the reduction of the growth rate (Currenta, 2009). Effective concentrations are based on the geometric mean of measured concentrations.
The study data were analysed on a 48 h basis, because the coefficient of
variation between daily sectional growth rates over 72 h exceeded 35 %.
As cell numbers increased well above 16-fold over 48 h, and all other
validity criteria are met, this is an option explicitly covered by OECD
TG 201 (2006) and EU method C.3 (2009).
Furthermore, effects based on the biomass were reported yielding more
sensitive results than effects based on the growth rate. But, according
to the Guidance Document R.7b (ECHA, 2008) results based on the biomass
should not be used for assessment since biomass results depend on the
growth rate of the species as well as the test duration and other
elements of the test design. Thus, the results based on the biomass are
not used for the hazard assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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