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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Some study details are missing. However, method and results are sufficiently described.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
The formation of mercapturic acids. 1. Formation of mercapturic acid and the levels of glutathione in tissues.
Author:
Barnes MM, James SP, Wood PB
Year:
1959
Bibliographic source:
Biochem J 71: 680 - 690
Reference Type:
review article or handbook
Title:
OECD-Screening Information DataSet (SIDS) for High Production Volume Chemicals: 1,2-Dichloro-4-nitrobenzene
Author:
UNEP (United Nations Environmental Program - Chemical Branch)
Year:
2005
Bibliographic source:
United Nations

Materials and methods

Objective of study:
excretion
Principles of method if other than guideline:
Method: other: see freetext TC
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
IUCLID4 Test substance: other TS: 1,2-dichloro-4-nitrobenzene, no data on purity
Radiolabelling:
other: migrated dataset

Test animals

Species:
rat
Strain:
other: migrated dataset

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Duration and frequency of treatment / exposure:
migrated dataset
Doses / concentrations
Remarks:
Doses / Concentrations:
Females: I. 1820 µmole/kg bw (ca. 350 mg/kg bw); II. 1300 or 1820 µmole/kg bw (ca. 250 or 350 mg/kg bw)
No. of animals per sex per dose:
migrated dataset

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on absorption:
migrated dataset
Details on distribution in tissues:
migrated dataset
Details on excretion:
migrated dataset
Toxicokinetic parameters
Toxicokinetic parameters:
other: migrated dataset

Any other information on results incl. tables

RS-Freetext:
I. About 19 % (range 4 - 29 %) of the applied dose was
excreted as mercapturic acid in urine within 24 hrs.
II. The maximum rate for excretion of mercapturic acid via
urine 2 - 6 days after dosing with 1300 or 1820 µmole/kg bw was
given with 10 or 21 µmole/kg bw/h.

Applicant's summary and conclusion

Executive summary:

1,2 -dichloro-4-nitrobenzene is excreted mainly via urine in the form of mercapturic acid derivate N-acetyl-S-(2 -chloro-4-nitrophenyl)-L-cysteine (UNEP 2005).